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- W1966687130 abstract "A short 543-bp fragment o f the pro-opiomelanocortin gene is sufficient for pituitary-specific expression and, in the anterior pituitary gland, for repression of pro-opiomelanocortin transcription by glucocorticoids. Within this 5′-flanking fragment of the gene, multiple regulatory elements contribute to tissue-specific expression and a single glucocorticoid receptor binding site acts as a “negative glucocorticoid response element.” The current model for glucocorticoid repression depends on the mutually exclusive binding of the glucocorticoid receptor and of a positive transcription factor, the chicken ovalbumin upstream promoter element transcription factor, to overlapping DNA sequences within the negative glucocorticoid response element." @default.
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- W1966687130 date "1990-03-01" @default.
- W1966687130 modified "2023-09-27" @default.
- W1966687130 title "Regulatory elements of the pro-opiomelanocortin gene pituitary specificity and glucocorticoid repression" @default.
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- W1966687130 doi "https://doi.org/10.1016/1043-2760(90)90056-9" @default.
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