FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966688035> ?p ?o ?g. }

• W1966688035 endingPage "380" @default.
• W1966688035 startingPage "368" @default.
• W1966688035 abstract "Abstract Background Pain constitutes the major non motor syndrome in Parkinson's disease ( PD ) and includes neuropathic pain; however current drug therapies used to alleviate it have only limited efficacy. This is probably due to poor understanding of the mechanisms underlying it. Aims We investigated a major class of trigeminal neuropathic pain, dynamic mechanical allodynia ( DMA ), in a rat model of PD and in which a bilateral 6‐hydroxy dopamine (6‐ OHDA ) injection was administered to produce a lesion of the nigrostriatal dopaminergic pathway. Results and discussion Lesioned animals presented significant DMA in the orofacial area that occurred from 4 days to 5 weeks post‐injury. To investigate a segmental implication in the neuropathic pain induced by dopamine depletion, the expression of the isoform gamma of the protein kinase C (PKCg) and phosphorylated extracellular signal‐regulated kinases 1/2 ( pERK 1/2) was explored in the medullary dorsal horn (MDH). There was a high increase in PKCg expression in the III and IIi laminae of the MDH of lesioned‐animals compared to shams. pERK 1/2 expression was also significantly high in the ipsilateral MDH of lesioned rats in response to non‐noxious tactile stimulus of the orofacial region. Since pERK 1/2 is expressed only in response to nociceptive stimuli in the dorsal spinal horn, the current study demonstrates that non‐noxious stimuli evoke allodynic response. Intraperitoneal and intracisternal administrations of bromocriptine, a dopamine 2 receptor (D2R) agonist, significantly decreased DMA compared to control rats injected with saline. These data demonstrate for the first time that nigrostriatal dopaminergic depletion produces trigeminal neuropathic pain that at least involves a segmental mechanism. In addition, bromocriptine was shown to have a remarkable analgesic effect on this neuropathic pain symptom." @default.
• W1966688035 created "2016-06-24" @default.
• W1966688035 creator A5021889273 @default.
• W1966688035 creator A5058485333 @default.
• W1966688035 creator A5058948419 @default.
• W1966688035 creator A5078352037 @default.
• W1966688035 date "2014-02-20" @default.
• W1966688035 modified "2023-10-14" @default.
• W1966688035 title "Lesion of the dopaminergic nigrostriatal pathway induces trigeminal dynamic mechanical allodynia" @default.
• W1966688035 cites W1530030261 @default.
• W1966688035 cites W1839543877 @default.
• W1966688035 cites W1926428507 @default.
• W1966688035 cites W1964600015 @default.
• W1966688035 cites W1967677380 @default.
• W1966688035 cites W1967849926 @default.
• W1966688035 cites W1978803477 @default.
• W1966688035 cites W1987243354 @default.
• W1966688035 cites W1991699170 @default.
• W1966688035 cites W1994305836 @default.
• W1966688035 cites W1994618304 @default.
• W1966688035 cites W2003542915 @default.
• W1966688035 cites W2003628930 @default.
• W1966688035 cites W2015413146 @default.
• W1966688035 cites W2023771303 @default.
• W1966688035 cites W2031051134 @default.
• W1966688035 cites W2031811175 @default.
• W1966688035 cites W2036459878 @default.
• W1966688035 cites W2039006502 @default.
• W1966688035 cites W2039024741 @default.
• W1966688035 cites W2040948176 @default.
• W1966688035 cites W2041591122 @default.
• W1966688035 cites W2042950525 @default.
• W1966688035 cites W2044860425 @default.
• W1966688035 cites W2045031596 @default.
• W1966688035 cites W2047615113 @default.
• W1966688035 cites W2050251142 @default.
• W1966688035 cites W2054128284 @default.
• W1966688035 cites W2057486642 @default.
• W1966688035 cites W2059025360 @default.
• W1966688035 cites W2062700118 @default.
• W1966688035 cites W2063132707 @default.
• W1966688035 cites W2064726106 @default.
• W1966688035 cites W2065296100 @default.
• W1966688035 cites W2066603875 @default.
• W1966688035 cites W2067734511 @default.
• W1966688035 cites W2069010931 @default.
• W1966688035 cites W2069155827 @default.
• W1966688035 cites W2069414159 @default.
• W1966688035 cites W2071127132 @default.
• W1966688035 cites W2078308586 @default.
• W1966688035 cites W2080855938 @default.
• W1966688035 cites W2080935562 @default.
• W1966688035 cites W2083366541 @default.
• W1966688035 cites W2084083432 @default.
• W1966688035 cites W2089633836 @default.
• W1966688035 cites W2093368672 @default.
• W1966688035 cites W2098783566 @default.
• W1966688035 cites W2099984156 @default.
• W1966688035 cites W2100268153 @default.
• W1966688035 cites W2122911349 @default.
• W1966688035 cites W2123297926 @default.
• W1966688035 cites W2128692107 @default.
• W1966688035 cites W2144952057 @default.
• W1966688035 cites W2155875767 @default.
• W1966688035 cites W2170099066 @default.
• W1966688035 cites W2171037951 @default.
• W1966688035 doi "https://doi.org/10.1002/brb3.214" @default.
• W1966688035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4055187" @default.
• W1966688035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24944866" @default.
• W1966688035 hasPublicationYear "2014" @default.
• W1966688035 type Work @default.
• W1966688035 sameAs 1966688035 @default.
• W1966688035 citedByCount "38" @default.
• W1966688035 countsByYear W19666880352015 @default.
• W1966688035 countsByYear W19666880352016 @default.
• W1966688035 countsByYear W19666880352017 @default.
• W1966688035 countsByYear W19666880352018 @default.
• W1966688035 countsByYear W19666880352019 @default.
• W1966688035 countsByYear W19666880352020 @default.
• W1966688035 countsByYear W19666880352021 @default.
• W1966688035 countsByYear W19666880352022 @default.
• W1966688035 countsByYear W19666880352023 @default.
• W1966688035 crossrefType "journal-article" @default.
• W1966688035 hasAuthorship W1966688035A5021889273 @default.
• W1966688035 hasAuthorship W1966688035A5058485333 @default.
• W1966688035 hasAuthorship W1966688035A5058948419 @default.
• W1966688035 hasAuthorship W1966688035A5078352037 @default.
• W1966688035 hasBestOaLocation W19666880351 @default.
• W1966688035 hasConcept C104211972 @default.
• W1966688035 hasConcept C126322002 @default.
• W1966688035 hasConcept C137183658 @default.
• W1966688035 hasConcept C141071460 @default.
• W1966688035 hasConcept C142724271 @default.
• W1966688035 hasConcept C15490471 @default.
• W1966688035 hasConcept C15744967 @default.
• W1966688035 hasConcept C159167319 @default.
• W1966688035 hasConcept C169760540 @default.
• W1966688035 hasConcept C170493617 @default.

• next