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- W1966689094 abstract "Tolerance against ischemia can be induced in the CA1 region of the hippocampus of the brain. In gerbils tolerance evolvement is blocked by the NMDA-antagonist MK-801. To examine this mechanism in rats, MK-801 was administered i.p. 1 h prior to tolerance inducing ischemia. Body temperature and activity were monitored before and after ischemia, and show that MK-801 results in hyperthermia immediately after the injection, the post-ischemic body temperature remain elevated until 5 h post-ischemia in spite of the animals being less active than control animals. Histology shows that pre-treatment with MK-801 does not affect the CA1 neuronal density, and we thus conclude that for the used rat model, MK-801 does not affect development of ischemic tolerance." @default.
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- W1966689094 date "2004-05-01" @default.
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- W1966689094 title "MK-801 does not prevent development of ischemic tolerance in rat brain" @default.
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- W1966689094 doi "https://doi.org/10.1097/00001756-200405190-00014" @default.
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