Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966695890> ?p ?o ?g. }
- W1966695890 endingPage "176" @default.
- W1966695890 startingPage "167" @default.
- W1966695890 abstract "Ondansetron is the drug of choice to prevent nausea in women undergoing cesarean surgery and can be used to prevent neonatal abstinence syndrome (NAS). The pharmacokinetics of ondansetron have not been characterized in pregnant women or in newborns. A nonlinear mixed-effects modeling approach was used to analyze plasma samples obtained from 20 nonpregnant and 40 pregnant women following a single administration of 4 or 8 mg ondansetron, from umbilical cord blood at delivery, and from neonates after birth. The analysis indicates that: ondansetron disposition is not affected by pregnancy (P > 0.05), but influenced by dose (P < 0.05), and is characterized by rapid transplacental transfer and longer elimination half-life in neonates compared to their mother. A dosing regimen for prevention of NAS was designed based on the model. The regimen involves IV administration of 4 mg to the mothers shortly before cord clamping, or oral administration of 0.07 mg/kg (or equivalently 0.04 mg/kg IV) to neonates." @default.
- W1966695890 created "2016-06-24" @default.
- W1966695890 creator A5008864082 @default.
- W1966695890 creator A5012198186 @default.
- W1966695890 creator A5016077008 @default.
- W1966695890 creator A5016419819 @default.
- W1966695890 creator A5027728661 @default.
- W1966695890 creator A5039629344 @default.
- W1966695890 creator A5046862537 @default.
- W1966695890 creator A5079478687 @default.
- W1966695890 date "2014-12-04" @default.
- W1966695890 modified "2023-10-18" @default.
- W1966695890 title "Ondansetron Pharmacokinetics in Pregnant Women and Neonates: Towards a New Treatment for Neonatal Abstinence Syndrome" @default.
- W1966695890 cites W1597879068 @default.
- W1966695890 cites W1928789054 @default.
- W1966695890 cites W1974912928 @default.
- W1966695890 cites W1978627738 @default.
- W1966695890 cites W1978796687 @default.
- W1966695890 cites W1978867369 @default.
- W1966695890 cites W1980476299 @default.
- W1966695890 cites W1981830699 @default.
- W1966695890 cites W1988703513 @default.
- W1966695890 cites W1999142590 @default.
- W1966695890 cites W2021256567 @default.
- W1966695890 cites W2038501458 @default.
- W1966695890 cites W2041539882 @default.
- W1966695890 cites W2042422908 @default.
- W1966695890 cites W2042553471 @default.
- W1966695890 cites W2047082271 @default.
- W1966695890 cites W2054471735 @default.
- W1966695890 cites W2058734479 @default.
- W1966695890 cites W2066857282 @default.
- W1966695890 cites W2078006985 @default.
- W1966695890 cites W2085651211 @default.
- W1966695890 cites W2127807759 @default.
- W1966695890 cites W2133037325 @default.
- W1966695890 cites W2159601567 @default.
- W1966695890 cites W2169906777 @default.
- W1966695890 cites W2295009677 @default.
- W1966695890 cites W2324009116 @default.
- W1966695890 cites W2337859167 @default.
- W1966695890 cites W2397599437 @default.
- W1966695890 cites W2400253520 @default.
- W1966695890 cites W2406034181 @default.
- W1966695890 cites W319497590 @default.
- W1966695890 doi "https://doi.org/10.1002/cpt.5" @default.
- W1966695890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4325425" @default.
- W1966695890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25670522" @default.
- W1966695890 hasPublicationYear "2014" @default.
- W1966695890 type Work @default.
- W1966695890 sameAs 1966695890 @default.
- W1966695890 citedByCount "27" @default.
- W1966695890 countsByYear W19666958902015 @default.
- W1966695890 countsByYear W19666958902016 @default.
- W1966695890 countsByYear W19666958902017 @default.
- W1966695890 countsByYear W19666958902018 @default.
- W1966695890 countsByYear W19666958902019 @default.
- W1966695890 countsByYear W19666958902020 @default.
- W1966695890 countsByYear W19666958902021 @default.
- W1966695890 countsByYear W19666958902022 @default.
- W1966695890 countsByYear W19666958902023 @default.
- W1966695890 crossrefType "journal-article" @default.
- W1966695890 hasAuthorship W1966695890A5008864082 @default.
- W1966695890 hasAuthorship W1966695890A5012198186 @default.
- W1966695890 hasAuthorship W1966695890A5016077008 @default.
- W1966695890 hasAuthorship W1966695890A5016419819 @default.
- W1966695890 hasAuthorship W1966695890A5027728661 @default.
- W1966695890 hasAuthorship W1966695890A5039629344 @default.
- W1966695890 hasAuthorship W1966695890A5046862537 @default.
- W1966695890 hasAuthorship W1966695890A5079478687 @default.
- W1966695890 hasBestOaLocation W19666958902 @default.
- W1966695890 hasConcept C105702510 @default.
- W1966695890 hasConcept C112705442 @default.
- W1966695890 hasConcept C126322002 @default.
- W1966695890 hasConcept C131872663 @default.
- W1966695890 hasConcept C2776955114 @default.
- W1966695890 hasConcept C2777170512 @default.
- W1966695890 hasConcept C2779234561 @default.
- W1966695890 hasConcept C2780580376 @default.
- W1966695890 hasConcept C2781413609 @default.
- W1966695890 hasConcept C42219234 @default.
- W1966695890 hasConcept C54355233 @default.
- W1966695890 hasConcept C71924100 @default.
- W1966695890 hasConcept C86803240 @default.
- W1966695890 hasConcept C98274493 @default.
- W1966695890 hasConceptScore W1966695890C105702510 @default.
- W1966695890 hasConceptScore W1966695890C112705442 @default.
- W1966695890 hasConceptScore W1966695890C126322002 @default.
- W1966695890 hasConceptScore W1966695890C131872663 @default.
- W1966695890 hasConceptScore W1966695890C2776955114 @default.
- W1966695890 hasConceptScore W1966695890C2777170512 @default.
- W1966695890 hasConceptScore W1966695890C2779234561 @default.
- W1966695890 hasConceptScore W1966695890C2780580376 @default.
- W1966695890 hasConceptScore W1966695890C2781413609 @default.
- W1966695890 hasConceptScore W1966695890C42219234 @default.
- W1966695890 hasConceptScore W1966695890C54355233 @default.
- W1966695890 hasConceptScore W1966695890C71924100 @default.
- W1966695890 hasConceptScore W1966695890C86803240 @default.