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• W1966696376 abstract "We evaluated whether DNA immunization with HIV-1 regulatory genes change natural killer (NK) effector cell activity. NK cells are the most important cells for the immediate host defense against virus-infected and tumor cells. We analyzed the NK activities of HIV-1-infected individuals against K562 cells (the classical assay) as well as against a CD4+ cell line with and without HIV-1 infection. CD4+ T lymphocytes are the main target cells for HIV-1 infection in vivo. Various proportions of the CD4+ T lymphocyte population carry the HIV-1 genome, produce virus and contribute to the systemic spread of HIV-1.CD4+ cell lines were established through HTLV-1 transformation which made the cells susceptible to NK lysis. NK activity was then tested in a (51)Cr release assay.NK cells of asymptomatic HIV-infected individuals mediated considerable lytic activity against K562 cells as well as against the uninfected and HIV-1-infected CD4+ cell line, and so did the NK cells of HIV-1-infected patients on highly active antiretroviral treatment.DNA immunization with HIV-1-regulatory genes did not significantly change the NK effector cell activity." @default.
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• W1966696376 date "2000-01-01" @default.
• W1966696376 modified "2023-10-01" @default.
• W1966696376 title "Human Natural Killer Cells in Asymptomatic Human Immunodeficiency Virus-1 Infection" @default.
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• W1966696376 doi "https://doi.org/10.1159/000053997" @default.
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