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• W1966704731 abstract "A growing body of research documents the quality and magnitude of olfactory dysfunction manifest by individuals with neurologic and psychiatric disorders. Evidence from studies of patients with neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases indicate that olfactory deficits are marked (see Doty 1991). In contrast, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced parkinsonism (MPTP-P; Doty et al 1992a) Korsakoff’s amnestic syndrome (Jones et al 1975), amyotrophic lateral sclerosis (ALS; Sajjadian et al 1994), and Huntington’s disease (HD; Doty 1991; Moberg et al 1987) are associated with less severe olfactory decrements. Individuals with multiple sclerosis (MS; Kesslak et al 1988) and progressive supranuclear palsy (PSP; Doty et al 1993) are reported to have intact olfactory ability. With reference to psychiatric disorders, only those with schizophrenia (Hurwitz et al 1988; Kopala et al 1992; Seidman et al 1992) and obsessive–compulsive disorder (Goldberg et al 1991) have impaired olfactory function. The magnitude of the dysfunction is in the mild range. Studies of panic disorder (Kopala and Good in press), anorexia nervosa (Kopala et al 1995a; Federoff et al 1995), and possibly depression (Amsterdam et al 1987; Warner et al 1990) report no impairment on tasks assessing olfactory function. Given the wide range of disorders of the central nervous system that are associated with olfactory compromise, a single etiology for observed olfactory dysfunction is unlikely; however, overlapping neuropathological substrate may assist in delineating the abnormal brain regions responsible for olfactory deficits. From a clinical perspective, assessing olfactory function in certain patient groups may be valuable for differential diagnosis and early intervention. In light of the existing literature and promise of olfactory measures as indices of central nervous system (CNS) function, this review is proffered with the following objectives:" @default.
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• W1966704731 date "1997-10-01" @default.
• W1966704731 modified "2023-09-23" @default.
• W1966704731 title "Olfactory Dysfunction in Neuropsychiatric Disorders: Review and Methodological Considerations" @default.
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• W1966704731 doi "https://doi.org/10.1016/s0006-3223(96)00442-8" @default.
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