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- W1966709046 abstract "The effects of a phorbol ester, 12-deoxyphorbol 13-isobutyrate (DPB), on contraction of isolated vascular smooth muscle of rat aorta were examined. DPB (100 nM-1 microM) induced a concentration-dependent contraction in resting aorta. DPB (3-100 nM) also induced a concentration-dependent relaxation of the norepinephrine-induced contraction. The contractile effect of DPB was potentiated whereas the relaxant effect was inhibited by endothelium removal or by methylene blue, suggesting that lower concentrations of DPB release endothelium-derived relaxing factor to inhibit contraction in rat aorta." @default.
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- W1966709046 date "1990-04-01" @default.
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- W1966709046 title "Phorbol ester-induced release of endothelium-derived relaxing factor" @default.
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- W1966709046 doi "https://doi.org/10.1016/0014-2999(90)90420-b" @default.
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