FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966711704> ?p ?o ?g. }

• W1966711704 endingPage "11" @default.
• W1966711704 startingPage "6" @default.
• W1966711704 abstract "Inflammatory bone destruction triggered by oral bacteria is a hallmark of chronic and apical periodontitis. Receptor activator of NF-κB ligand (RANKL) activates bone resorption, whereas osteoprotegerin (OPG) blocks its action. These are members of the tumor necrosis factor ligand and receptor families, respectively. Although individual oral pathogens are known to regulate RANKL and OPG expression in cells of relevance to the respective diseases, such as periodontal ligament (PDL) and dental pulp (DP) cells, the effect of polymicrobial oral biofilms is not known. This study aimed to investigate the effect of the Zürich in vitro supragingival biofilm model on RANKL and OPG gene expression, in human PDL and DP cell cultures, by quantitative real-time polymerase chain reaction. RANKL expression was more pronouncedly up-regulated in DP than PDL cells (4-fold greater), whereas OPG was up-regulated to a similar extent. The RANKL/OPG ratio was increased only in DP cells, indicating an enhanced capacity for inducing bone resorption. The expression of pro-inflammatory cytokine interleukin-1β was also increased in DP, but not PDL cells. Collectively, the high responsiveness of DP, but not PDL cells to the supragingival biofilm challenge could constitute a putative pathogenic mechanism for apical periodontitis, which may not crucial for chronic periodontitis." @default.
• W1966711704 created "2016-06-24" @default.
• W1966711704 creator A5025915071 @default.
• W1966711704 creator A5073538546 @default.
• W1966711704 creator A5089096323 @default.
• W1966711704 creator A5091550045 @default.
• W1966711704 date "2011-01-01" @default.
• W1966711704 modified "2023-10-18" @default.
• W1966711704 title "Oral biofilm challenge regulates the RANKL-OPG system in periodontal ligament and dental pulp cells" @default.
• W1966711704 cites W1526205867 @default.
• W1966711704 cites W1968268556 @default.
• W1966711704 cites W1989703775 @default.
• W1966711704 cites W1993678845 @default.
• W1966711704 cites W1999559229 @default.
• W1966711704 cites W2000647744 @default.
• W1966711704 cites W2023294259 @default.
• W1966711704 cites W2025934097 @default.
• W1966711704 cites W2027484047 @default.
• W1966711704 cites W2028635293 @default.
• W1966711704 cites W2036932056 @default.
• W1966711704 cites W2045169251 @default.
• W1966711704 cites W2048299560 @default.
• W1966711704 cites W2053798698 @default.
• W1966711704 cites W2057664891 @default.
• W1966711704 cites W2058365833 @default.
• W1966711704 cites W2065297127 @default.
• W1966711704 cites W2070791176 @default.
• W1966711704 cites W2071805546 @default.
• W1966711704 cites W2074613338 @default.
• W1966711704 cites W2074881372 @default.
• W1966711704 cites W2081527623 @default.
• W1966711704 cites W2089453517 @default.
• W1966711704 cites W2090543816 @default.
• W1966711704 cites W2093111652 @default.
• W1966711704 cites W2098502218 @default.
• W1966711704 cites W2107810489 @default.
• W1966711704 cites W2111302020 @default.
• W1966711704 cites W2111797342 @default.
• W1966711704 cites W2125009415 @default.
• W1966711704 cites W2145256793 @default.
• W1966711704 cites W2167361522 @default.
• W1966711704 doi "https://doi.org/10.1016/j.micpath.2010.11.002" @default.
• W1966711704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21075196" @default.
• W1966711704 hasPublicationYear "2011" @default.
• W1966711704 type Work @default.
• W1966711704 sameAs 1966711704 @default.
• W1966711704 citedByCount "39" @default.
• W1966711704 countsByYear W19667117042012 @default.
• W1966711704 countsByYear W19667117042013 @default.
• W1966711704 countsByYear W19667117042014 @default.
• W1966711704 countsByYear W19667117042015 @default.
• W1966711704 countsByYear W19667117042016 @default.
• W1966711704 countsByYear W19667117042017 @default.
• W1966711704 countsByYear W19667117042018 @default.
• W1966711704 countsByYear W19667117042019 @default.
• W1966711704 countsByYear W19667117042021 @default.
• W1966711704 countsByYear W19667117042022 @default.
• W1966711704 countsByYear W19667117042023 @default.
• W1966711704 crossrefType "journal-article" @default.
• W1966711704 hasAuthorship W1966711704A5025915071 @default.
• W1966711704 hasAuthorship W1966711704A5073538546 @default.
• W1966711704 hasAuthorship W1966711704A5089096323 @default.
• W1966711704 hasAuthorship W1966711704A5091550045 @default.
• W1966711704 hasConcept C126322002 @default.
• W1966711704 hasConcept C170493617 @default.
• W1966711704 hasConcept C185592680 @default.
• W1966711704 hasConcept C199343813 @default.
• W1966711704 hasConcept C2776033226 @default.
• W1966711704 hasConcept C2779337755 @default.
• W1966711704 hasConcept C2779428903 @default.
• W1966711704 hasConcept C2780385504 @default.
• W1966711704 hasConcept C2780426850 @default.
• W1966711704 hasConcept C41868710 @default.
• W1966711704 hasConcept C55493867 @default.
• W1966711704 hasConcept C673006 @default.
• W1966711704 hasConcept C71924100 @default.
• W1966711704 hasConcept C86803240 @default.
• W1966711704 hasConcept C88045685 @default.
• W1966711704 hasConcept C95444343 @default.
• W1966711704 hasConceptScore W1966711704C126322002 @default.
• W1966711704 hasConceptScore W1966711704C170493617 @default.
• W1966711704 hasConceptScore W1966711704C185592680 @default.
• W1966711704 hasConceptScore W1966711704C199343813 @default.
• W1966711704 hasConceptScore W1966711704C2776033226 @default.
• W1966711704 hasConceptScore W1966711704C2779337755 @default.
• W1966711704 hasConceptScore W1966711704C2779428903 @default.
• W1966711704 hasConceptScore W1966711704C2780385504 @default.
• W1966711704 hasConceptScore W1966711704C2780426850 @default.
• W1966711704 hasConceptScore W1966711704C41868710 @default.
• W1966711704 hasConceptScore W1966711704C55493867 @default.
• W1966711704 hasConceptScore W1966711704C673006 @default.
• W1966711704 hasConceptScore W1966711704C71924100 @default.
• W1966711704 hasConceptScore W1966711704C86803240 @default.
• W1966711704 hasConceptScore W1966711704C88045685 @default.
• W1966711704 hasConceptScore W1966711704C95444343 @default.
• W1966711704 hasIssue "1" @default.
• W1966711704 hasLocation W19667117041 @default.
• W1966711704 hasLocation W19667117042 @default.

• next