Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966712135> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1966712135 endingPage "1192" @default.
- W1966712135 startingPage "1188" @default.
- W1966712135 abstract "Markedly obese athletes like Japanese sumo wrestlers may frequently suffer various traumas which result in the prophylaxis or treatment of posttraumatic infection with antibiotics. However, appropriate dosage regimens in this group of patients have not been fully known for many antibiotics. Therefore, we studied the kinetic disposition of cefotiam, a parenteral, broad-spectrum cephalosporin with activity against gram-positive and -negative bacteria, after an intravenous dose (2 g) infused over 30 min into 15 sumo wrestler patients with an excess body weight (130 to 220% of ideal body weight) and 10 control patients with a normal weight (90 to 102% of ideal body weight). Mean (+/- standard deviation) clearance and steady-state volume of distribution were significantly greater in the sumo wrestler than in the control group (38.3 +/- 9.4 versus 23.5 +/- 6.0 liters/h, P less than 0.001, and 30.2 +/- 8.0 versus 17.9 +/- 6.1 liters, P less than 0.001). Mean elimination half-life was slightly but significantly longer in the sumo wrestler than in the control group (0.91 +/- 0.14 versus 0.74 +/- 0.20 h, P less than 0.05). However, mean residence time did not differ between the two groups (0.79 +/- 0.10 versus 0.75 +/- 0.14 h). The statistical differences in clearance and volume of distribution between the two groups disappeared when these kinetic parameters were corrected for body surface area, but not for total body weight or ideal body weight. The results suggest that the dosage calculation of cefotiam, a hydrophilic antibiotic, should be made on the basis of body surface area in morbidly obese athlete or sumo wrestler patients. However, whether this recommendation should extend to other nonathlete obese subjects remains to be determined." @default.
- W1966712135 created "2016-06-24" @default.
- W1966712135 creator A5004395792 @default.
- W1966712135 creator A5029910624 @default.
- W1966712135 creator A5031940592 @default.
- W1966712135 creator A5036445805 @default.
- W1966712135 creator A5062376392 @default.
- W1966712135 creator A5069201375 @default.
- W1966712135 date "1989-08-01" @default.
- W1966712135 modified "2023-10-11" @default.
- W1966712135 title "Cefotiam disposition in markedly obese athlete patients, Japanese sumo wrestlers" @default.
- W1966712135 cites W1986679499 @default.
- W1966712135 cites W1989067938 @default.
- W1966712135 cites W2002609036 @default.
- W1966712135 cites W2011818075 @default.
- W1966712135 cites W2026916492 @default.
- W1966712135 cites W2029306560 @default.
- W1966712135 cites W2035018532 @default.
- W1966712135 cites W2067312325 @default.
- W1966712135 cites W2070225078 @default.
- W1966712135 cites W2079427385 @default.
- W1966712135 cites W2087526401 @default.
- W1966712135 cites W2094266750 @default.
- W1966712135 cites W2135536591 @default.
- W1966712135 cites W2419226087 @default.
- W1966712135 cites W2502670554 @default.
- W1966712135 doi "https://doi.org/10.1128/aac.33.8.1188" @default.
- W1966712135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/172622" @default.
- W1966712135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2802548" @default.
- W1966712135 hasPublicationYear "1989" @default.
- W1966712135 type Work @default.
- W1966712135 sameAs 1966712135 @default.
- W1966712135 citedByCount "18" @default.
- W1966712135 countsByYear W19667121352012 @default.
- W1966712135 countsByYear W19667121352013 @default.
- W1966712135 countsByYear W19667121352016 @default.
- W1966712135 countsByYear W19667121352019 @default.
- W1966712135 crossrefType "journal-article" @default.
- W1966712135 hasAuthorship W1966712135A5004395792 @default.
- W1966712135 hasAuthorship W1966712135A5029910624 @default.
- W1966712135 hasAuthorship W1966712135A5031940592 @default.
- W1966712135 hasAuthorship W1966712135A5036445805 @default.
- W1966712135 hasAuthorship W1966712135A5062376392 @default.
- W1966712135 hasAuthorship W1966712135A5069201375 @default.
- W1966712135 hasBestOaLocation W19667121351 @default.
- W1966712135 hasConcept C112705442 @default.
- W1966712135 hasConcept C126322002 @default.
- W1966712135 hasConcept C139254425 @default.
- W1966712135 hasConcept C141071460 @default.
- W1966712135 hasConcept C147583825 @default.
- W1966712135 hasConcept C185592680 @default.
- W1966712135 hasConcept C2778752919 @default.
- W1966712135 hasConcept C42219234 @default.
- W1966712135 hasConcept C501593827 @default.
- W1966712135 hasConcept C55493867 @default.
- W1966712135 hasConcept C64778159 @default.
- W1966712135 hasConcept C71924100 @default.
- W1966712135 hasConcept C90924648 @default.
- W1966712135 hasConceptScore W1966712135C112705442 @default.
- W1966712135 hasConceptScore W1966712135C126322002 @default.
- W1966712135 hasConceptScore W1966712135C139254425 @default.
- W1966712135 hasConceptScore W1966712135C141071460 @default.
- W1966712135 hasConceptScore W1966712135C147583825 @default.
- W1966712135 hasConceptScore W1966712135C185592680 @default.
- W1966712135 hasConceptScore W1966712135C2778752919 @default.
- W1966712135 hasConceptScore W1966712135C42219234 @default.
- W1966712135 hasConceptScore W1966712135C501593827 @default.
- W1966712135 hasConceptScore W1966712135C55493867 @default.
- W1966712135 hasConceptScore W1966712135C64778159 @default.
- W1966712135 hasConceptScore W1966712135C71924100 @default.
- W1966712135 hasConceptScore W1966712135C90924648 @default.
- W1966712135 hasIssue "8" @default.
- W1966712135 hasLocation W19667121351 @default.
- W1966712135 hasLocation W19667121352 @default.
- W1966712135 hasLocation W19667121353 @default.
- W1966712135 hasOpenAccess W1966712135 @default.
- W1966712135 hasPrimaryLocation W19667121351 @default.
- W1966712135 hasRelatedWork W1987505991 @default.
- W1966712135 hasRelatedWork W2019022133 @default.
- W1966712135 hasRelatedWork W2082998857 @default.
- W1966712135 hasRelatedWork W2090307551 @default.
- W1966712135 hasRelatedWork W2155041980 @default.
- W1966712135 hasRelatedWork W2207549972 @default.
- W1966712135 hasRelatedWork W2351351947 @default.
- W1966712135 hasRelatedWork W2367999783 @default.
- W1966712135 hasRelatedWork W2749464292 @default.
- W1966712135 hasRelatedWork W2890235063 @default.
- W1966712135 hasVolume "33" @default.
- W1966712135 isParatext "false" @default.
- W1966712135 isRetracted "false" @default.
- W1966712135 magId "1966712135" @default.
- W1966712135 workType "article" @default.