Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966712908> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1966712908 endingPage "384" @default.
- W1966712908 startingPage "379" @default.
- W1966712908 abstract "Although canine mammary tumours (CMT) are the most common malignant tumours in bitches the pathogenesis is far from understood. To analyse the role of the transforming growth factor β (TGFβ) family in the carcinogenesis of CMT, relative mRNA and protein expression of TGFβ-1, -2 and -3, TGFβ receptor (TGFβR)-1 and -3, latent TGFβ-binding protein (LTBP)-1, -3 and -4, and oestrogen receptor α in CMT were quantified. mRNA expression concentrations were measured in laser-microdissected tissue samples of mammary adenomas, carcinomas and their lymph node metastases and normalised to the non-neoplastic mammary gland of the same dog. Carcinomas and metastases had significantly decreased expression levels of TGFβ-3, TGFβR-3 and LTBP-4, but increased LTBP-1 expression when compared to non-neoplastic glands or adenomas. Decreased TGFβ and LTBP-4 expression were confirmed immunohistochemically. The data suggested that loss of TGFβ-3 and LTBP-4 may have growth-stimulatory effects in late-stage tumours, and loss of their expression, together with reduced TGFβR-3 expression, may be associated with increased proliferative activity of CMT similar to findings in human breast cancer." @default.
- W1966712908 created "2016-06-24" @default.
- W1966712908 creator A5011041473 @default.
- W1966712908 creator A5011653179 @default.
- W1966712908 creator A5051048940 @default.
- W1966712908 date "2010-12-01" @default.
- W1966712908 modified "2023-09-23" @default.
- W1966712908 title "Downregulation of transforming growth factor β (TGFβ) and latent TGFβ binding protein (LTBP)-4 expression in late stage canine mammary tumours" @default.
- W1966712908 cites W1508632532 @default.
- W1966712908 cites W1522126893 @default.
- W1966712908 cites W1577577364 @default.
- W1966712908 cites W1658281193 @default.
- W1966712908 cites W1975324295 @default.
- W1966712908 cites W1979788221 @default.
- W1966712908 cites W2010871781 @default.
- W1966712908 cites W2013701595 @default.
- W1966712908 cites W2014546243 @default.
- W1966712908 cites W2041172831 @default.
- W1966712908 cites W2064331438 @default.
- W1966712908 cites W2082349091 @default.
- W1966712908 cites W2091215847 @default.
- W1966712908 cites W2092104789 @default.
- W1966712908 cites W2107277218 @default.
- W1966712908 cites W2126855363 @default.
- W1966712908 cites W2139930644 @default.
- W1966712908 cites W2277013638 @default.
- W1966712908 cites W4236862968 @default.
- W1966712908 cites W4249611398 @default.
- W1966712908 doi "https://doi.org/10.1016/j.tvjl.2009.09.014" @default.
- W1966712908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19836277" @default.
- W1966712908 hasPublicationYear "2010" @default.
- W1966712908 type Work @default.
- W1966712908 sameAs 1966712908 @default.
- W1966712908 citedByCount "17" @default.
- W1966712908 countsByYear W19667129082013 @default.
- W1966712908 countsByYear W19667129082014 @default.
- W1966712908 countsByYear W19667129082016 @default.
- W1966712908 countsByYear W19667129082017 @default.
- W1966712908 countsByYear W19667129082019 @default.
- W1966712908 countsByYear W19667129082020 @default.
- W1966712908 countsByYear W19667129082021 @default.
- W1966712908 crossrefType "journal-article" @default.
- W1966712908 hasAuthorship W1966712908A5011041473 @default.
- W1966712908 hasAuthorship W1966712908A5011653179 @default.
- W1966712908 hasAuthorship W1966712908A5051048940 @default.
- W1966712908 hasConcept C104317684 @default.
- W1966712908 hasConcept C118131993 @default.
- W1966712908 hasConcept C121608353 @default.
- W1966712908 hasConcept C126322002 @default.
- W1966712908 hasConcept C127561419 @default.
- W1966712908 hasConcept C134018914 @default.
- W1966712908 hasConcept C142724271 @default.
- W1966712908 hasConcept C2778001805 @default.
- W1966712908 hasConcept C502942594 @default.
- W1966712908 hasConcept C530470458 @default.
- W1966712908 hasConcept C55493867 @default.
- W1966712908 hasConcept C555283112 @default.
- W1966712908 hasConcept C71924100 @default.
- W1966712908 hasConcept C86803240 @default.
- W1966712908 hasConceptScore W1966712908C104317684 @default.
- W1966712908 hasConceptScore W1966712908C118131993 @default.
- W1966712908 hasConceptScore W1966712908C121608353 @default.
- W1966712908 hasConceptScore W1966712908C126322002 @default.
- W1966712908 hasConceptScore W1966712908C127561419 @default.
- W1966712908 hasConceptScore W1966712908C134018914 @default.
- W1966712908 hasConceptScore W1966712908C142724271 @default.
- W1966712908 hasConceptScore W1966712908C2778001805 @default.
- W1966712908 hasConceptScore W1966712908C502942594 @default.
- W1966712908 hasConceptScore W1966712908C530470458 @default.
- W1966712908 hasConceptScore W1966712908C55493867 @default.
- W1966712908 hasConceptScore W1966712908C555283112 @default.
- W1966712908 hasConceptScore W1966712908C71924100 @default.
- W1966712908 hasConceptScore W1966712908C86803240 @default.
- W1966712908 hasIssue "3" @default.
- W1966712908 hasLocation W19667129081 @default.
- W1966712908 hasLocation W19667129082 @default.
- W1966712908 hasOpenAccess W1966712908 @default.
- W1966712908 hasPrimaryLocation W19667129081 @default.
- W1966712908 hasRelatedWork W2002315461 @default.
- W1966712908 hasRelatedWork W2016202130 @default.
- W1966712908 hasRelatedWork W2020449916 @default.
- W1966712908 hasRelatedWork W2026301838 @default.
- W1966712908 hasRelatedWork W2033672302 @default.
- W1966712908 hasRelatedWork W2155981800 @default.
- W1966712908 hasRelatedWork W2740221126 @default.
- W1966712908 hasRelatedWork W3090788604 @default.
- W1966712908 hasRelatedWork W4248212310 @default.
- W1966712908 hasRelatedWork W4252963116 @default.
- W1966712908 hasVolume "186" @default.
- W1966712908 isParatext "false" @default.
- W1966712908 isRetracted "false" @default.
- W1966712908 magId "1966712908" @default.
- W1966712908 workType "article" @default.