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- W1966721489 abstract "Abstract Morphine and the opioid peptides cause isolated segments of rat colon to contract and relax rhythmically. This study re-examines two hypotheses to explain this phenomenon: Release of 5-hydroxytryptamine (5-HT)/acetylcholine by morphine or inhibition of a tonically active non-adrenergic, non-cholinergic (NANC) inhibitory mechanism. Rhythmic contractions induced by morphine (5 × 10−6 M) were naloxone sensitive (10−6 M) but unaffected by methysergide (10−6 M), atropine (10−6 M) or pretreatment of rats with p-chlorophenylalanine (200 mg kg−1 i.p. for four days) which lowered the 5-HT level in the colon from 3·73 ± 0·83 mg g−1 in controls to 0·41 ± 0·06 mg g−1 (P < 0·001). The pattern of rhythmic contractions produced by morphine was unlike those produced by 5-HT (5 × 10−6 M), acetylcholine (5 × 10−6 M) or potassium chloride (30 mM). Tetrodotoxin (10−6 M), apamin (10−8 M), clonidine (2 × 10−8 M), phentolamine (10−5 M) or oxprenolol (10−5 M) caused rhythmic contractions which were unaffected by naloxone. Clonidine contractions were inhibited by yohimbine (10−7 M) but not by prazosin (10−6 M). Electrical field stimulation at the peak of a contraction induced by morphine, apamin or Clonidine, produced an inhibitory response which was unaffected by atropine, phentolamine, propranolol and guanethidine (all 10−5 M). It persisted in colon segments from rats pretreated with reserpine or 6-hydroxydopamine. These results suggest that neither the 5-HT/acetylcholine hypothesis nor inhibition of the NANC mechanism adequately explains the excitatory effect of morphine in the rat colon." @default.
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- W1966721489 date "1989-11-01" @default.
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- W1966721489 title "Excitatory Effect of Morphine and Opioid Peptides in the Rat Isolated Colon" @default.
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- W1966721489 doi "https://doi.org/10.1111/j.2042-7158.1989.tb06359.x" @default.
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