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- W1966722929 endingPage "e113494" @default.
- W1966722929 startingPage "e113494" @default.
- W1966722929 abstract "The Drosophila neuromuscular junction (NMJ) is a glutamatergic synapse that is structurally and functionally similar to mammalian glutamatergic synapses. These synapses can, as a result of changes in activity, alter the strength of their connections via processes that require chromatin remodeling and changes in gene expression. The chromodomain helicase DNA binding (CHD) protein, Kismet (Kis), is expressed in both motor neuron nuclei and postsynaptic muscle nuclei of the Drosophila larvae. Here, we show that Kis is important for motor neuron synaptic morphology, the localization and clustering of postsynaptic glutamate receptors, larval motor behavior, and synaptic transmission. Our data suggest that Kis is part of the machinery that modulates the development and function of the NMJ. Kis is the homolog to human CHD7, which is mutated in CHARGE syndrome. Thus, our data suggest novel avenues of investigation for synaptic defects associated with CHARGE syndrome." @default.
- W1966722929 created "2016-06-24" @default.
- W1966722929 creator A5014294298 @default.
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- W1966722929 creator A5068366061 @default.
- W1966722929 creator A5079707091 @default.
- W1966722929 creator A5091209663 @default.
- W1966722929 date "2014-11-20" @default.
- W1966722929 modified "2023-10-13" @default.
- W1966722929 title "Kismet Positively Regulates Glutamate Receptor Localization and Synaptic Transmission at the Drosophila Neuromuscular Junction" @default.
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- W1966722929 doi "https://doi.org/10.1371/journal.pone.0113494" @default.
- W1966722929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4239079" @default.
- W1966722929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25412171" @default.
- W1966722929 hasPublicationYear "2014" @default.
- W1966722929 type Work @default.