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• W1966740195 abstract "Experiments were performed to identify the glycinergic or GABAergic nature, and the timing of discharge, of the neurons which produce chloride-dependent inhibitions on other bulbar respiratory neurons (RNs) during their silent and active phases. RNs recorded extracellularly in pentobarbital-anesthetized or decerebrate cats, were subjected to iontophoretic applications of glutamate, of the glycine antagonist strychnine, and of the GABAA receptor antagonist bicuculline. Both antagonists induced discharge or increased discharge frequency in restricted parts of the respiratory cycle without affecting the discharge frequency in other parts of the cycle. Strychnine most often elicited activity in late-inspiration and early-expiration, but also in early inspiration and in late expiration. Bicuculline was most often effective throughout the entire discharge period of each neuron with no effect during the silent period, although it also acted selectively during late-inspiration in inspiratory neurons, an effect attributed to GABAA receptor blockade. The convergence of glycinergic afferent inputs during late inspiration and early expiration suggests that glycinergic neurons may play an important role in the inspiratory to expiratory phase transition." @default.
• W1966740195 created "2016-06-24" @default.
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• W1966740195 date "1996-02-01" @default.
• W1966740195 modified "2023-10-15" @default.
• W1966740195 title "Inhibitions mediated by glycine and GABAA receptors shape the discharge pattern of bulbar respiratory neurons" @default.
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• W1966740195 doi "https://doi.org/10.1016/0006-8993(95)01380-6" @default.
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