FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966743075> ?p ?o ?g. }

• W1966743075 endingPage "455" @default.
• W1966743075 startingPage "444" @default.
• W1966743075 abstract "In an attempt to understand the regulatory mechanisms governing passage of neutrophils from the vascular bed to the interstitial tissue, we analyzed the effect of the pleiotropic monokines interleukin 1 (IL-1) and tumor necrosis factor (TNF) on transendothelial neutrophil traffic. Short-time preincubation of human umbilical vein endothelial cell (HUVE) monolayers with IL-1 and TNF led to an impressive time- and dose-dependent increase of endothelial cell-associated neutrophils when working in a full plasma system on petri dishes. Electron microscopic analysis revealed junctional penetration of monolayers by neutrophils. More quantitatively, when using a monolayer-on-filter-system, priming led to a severalfold increase in complete layer passage occurring in the absence of an external chemotactic gradient. Direct comparison with an upside-down modification of the system together with data demonstrating the vectorial behavior of such migration revealed that IL-1-stimulated transendothelial neutrophil traffic is polarized. The described enhancement of neutrophil transendothelial passage was found to be a unique feature of IL-1/TNF-activated HUVE since HUVE-dependent transmigration potentiation was not observed as a consequence of mere neutrophil attachment to endothelial cells (e.g., induced by Fc-mediated adherence of PMN to HUVE). IL-1 acts selectively on endothelial cells as demonstrated by total inhibition of its effect by actinomycin D. Moreover, IL-1 does not induce HUVE monolayers to secrete a chemotaxin, and the neutrophil passage guiding principle is removable from the HUVE surface by short trypsin exposure. Congruent results were obtained with human adult arterial as well as saphenous vein endothelial cells. As shown by blockade of neutrophil migration with pertussis toxin, IL-1- and TNF-inducible transendothelial migration can be dissected into an initial anchoring step, which is succeeded by active neutrophil migration, possibly along a putative endothelial membrane-bound gradient." @default.
• W1966743075 created "2016-06-24" @default.
• W1966743075 creator A5017134924 @default.
• W1966743075 creator A5034339696 @default.
• W1966743075 creator A5067714023 @default.
• W1966743075 creator A5069076007 @default.
• W1966743075 date "1989-02-01" @default.
• W1966743075 modified "2023-09-27" @default.
• W1966743075 title "Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage." @default.
• W1966743075 cites W1495149107 @default.
• W1966743075 cites W1504880517 @default.
• W1966743075 cites W1511643778 @default.
• W1966743075 cites W1536372529 @default.
• W1966743075 cites W1547897886 @default.
• W1966743075 cites W1569662926 @default.
• W1966743075 cites W1576430359 @default.
• W1966743075 cites W1578996543 @default.
• W1966743075 cites W1661062552 @default.
• W1966743075 cites W171459490 @default.
• W1966743075 cites W1742723043 @default.
• W1966743075 cites W1760532333 @default.
• W1966743075 cites W1902323822 @default.
• W1966743075 cites W1973832079 @default.
• W1966743075 cites W1977061769 @default.
• W1966743075 cites W1977363772 @default.
• W1966743075 cites W198956251 @default.
• W1966743075 cites W1989587262 @default.
• W1966743075 cites W1990329455 @default.
• W1966743075 cites W1996516841 @default.
• W1966743075 cites W1996614740 @default.
• W1966743075 cites W2002811764 @default.
• W1966743075 cites W2011135701 @default.
• W1966743075 cites W2013424896 @default.
• W1966743075 cites W2035737677 @default.
• W1966743075 cites W2035985781 @default.
• W1966743075 cites W2046648005 @default.
• W1966743075 cites W2055749103 @default.
• W1966743075 cites W2056225363 @default.
• W1966743075 cites W2056971106 @default.
• W1966743075 cites W2057905142 @default.
• W1966743075 cites W2061698776 @default.
• W1966743075 cites W2066196795 @default.
• W1966743075 cites W2066918889 @default.
• W1966743075 cites W2069892556 @default.
• W1966743075 cites W2110623508 @default.
• W1966743075 cites W2113642505 @default.
• W1966743075 cites W2125001573 @default.
• W1966743075 cites W2131547680 @default.
• W1966743075 cites W2138488715 @default.
• W1966743075 cites W2140678674 @default.
• W1966743075 cites W2157603347 @default.
• W1966743075 cites W2183353764 @default.
• W1966743075 cites W2287255503 @default.
• W1966743075 cites W2316398848 @default.
• W1966743075 cites W2410514958 @default.
• W1966743075 cites W2411308050 @default.
• W1966743075 cites W2424083168 @default.
• W1966743075 cites W2460301376 @default.
• W1966743075 cites W2461147539 @default.
• W1966743075 cites W4212982536 @default.
• W1966743075 cites W4213129189 @default.
• W1966743075 cites W6447436 @default.
• W1966743075 doi "https://doi.org/10.1172/jci113903" @default.
• W1966743075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/303700" @default.
• W1966743075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2643630" @default.
• W1966743075 hasPublicationYear "1989" @default.
• W1966743075 type Work @default.
• W1966743075 sameAs 1966743075 @default.
• W1966743075 citedByCount "309" @default.
• W1966743075 countsByYear W19667430752012 @default.
• W1966743075 countsByYear W19667430752013 @default.
• W1966743075 countsByYear W19667430752014 @default.
• W1966743075 countsByYear W19667430752015 @default.
• W1966743075 countsByYear W19667430752016 @default.
• W1966743075 countsByYear W19667430752019 @default.
• W1966743075 countsByYear W19667430752020 @default.
• W1966743075 countsByYear W19667430752021 @default.
• W1966743075 countsByYear W19667430752022 @default.
• W1966743075 crossrefType "journal-article" @default.
• W1966743075 hasAuthorship W1966743075A5017134924 @default.
• W1966743075 hasAuthorship W1966743075A5034339696 @default.
• W1966743075 hasAuthorship W1966743075A5067714023 @default.
• W1966743075 hasAuthorship W1966743075A5069076007 @default.
• W1966743075 hasBestOaLocation W19667430751 @default.
• W1966743075 hasConcept C123012128 @default.
• W1966743075 hasConcept C134018914 @default.
• W1966743075 hasConcept C170493617 @default.
• W1966743075 hasConcept C17991360 @default.
• W1966743075 hasConcept C202751555 @default.
• W1966743075 hasConcept C203014093 @default.
• W1966743075 hasConcept C2776992346 @default.
• W1966743075 hasConcept C2777411675 @default.
• W1966743075 hasConcept C2777834122 @default.
• W1966743075 hasConcept C54166955 @default.
• W1966743075 hasConcept C55493867 @default.
• W1966743075 hasConcept C86803240 @default.
• W1966743075 hasConcept C95444343 @default.
• W1966743075 hasConceptScore W1966743075C123012128 @default.

• next