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• W1966745046 abstract "Pulmonary arterial hypertension (PAH) is a devastating disease with poor prognosis. Despite novel medical therapies targeting PAH pathophysiology, right ventricular (RV) failure and sudden cardiac death account for the majority of deaths in these patients [ 1 Tateno S. Niwa K. Nakazawa M. et al. Risk factors for arrhythmia and late death in patients with right ventricle to pulmonary artery conduit repair—Japanese multicenter study. Int J Cardiol. 2006; 106: 373-381 Abstract Full Text Full Text PDF PubMed Scopus (15) Google Scholar , 2 Humbert M. A critical analysis of survival in idiopathic pulmonary arterial hypertension. Presse Med. 2010; 39: IS41-IS45 Google Scholar ]. There are a number of indicators used for assessing the course of the disease and patient prognosis [ 3 Humbert M. Sitbon O. Chaouat A. et al. Survival in patients with idiopathic, familial, anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation. 2010; 122: 156-163 Crossref PubMed Scopus (1096) Google Scholar , 4 Howard L. Prognostic factors in pulmonary arterial hypertension: assessing the course of the disease. Eur Respir Rev. 2011; 20: 236-242 Crossref PubMed Scopus (54) Google Scholar ] but there is still a need for identification of non-invasive risk markers for predicting patient outcome. Microvolt T-wave alternans (MTWA) is a well-known non-invasive predictor of ventricular arrhythmias in patients with cardiomyopathies of various etiologies [ 5 Chow T. Kereiakes D.J. Bartone C. et al. Prognostic utility of microvolt T-wave alternans in risk stratification of patients with ischemic cardiomyopathy. J Am Coll Cardiol. 2006; 47: 1820-1827 Abstract Full Text Full Text PDF PubMed Scopus (199) Google Scholar , 6 Gupta A. Hoang D. Karliner L. et al. Ability of microvolt T-wave alternans to modify risk assessment of ventricular tachyarrhythmic events: a meta-analysis. Am Heart J. 2012; 163: 354-364 Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar ]. Benoist et al. [ [7] Benoist D. Stones R. Drinkhill M. et al. Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2012; 302: H2381-H2395 Crossref PubMed Scopus (61) Google Scholar ] reported on increased probability of alternans in experimental rat model of RV failure induced by pulmonary hypertension, but MTWA has not been explored in patients with RV failure, especially those with PAH." @default.
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• W1966745046 date "2014-10-01" @default.
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• W1966745046 title "Microvolt T-wave alternans profile in patients with pulmonary arterial hypertension" @default.
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• W1966745046 doi "https://doi.org/10.1016/j.ijcard.2014.07.173" @default.
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