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• W1966746721 abstract "<b><i>Objective:</i></b> We decided to investigate the role of this polymorphism on cardiovascular risk factors and weight loss secondary to a high-protein/low-carbohydrate vs. a standard hypocaloric diet (1,000 kcal/day) over a period of 9 months. <b><i>Material and methods:</i></b> A nutritional evaluation was performed at the beginning and at the end of a 9-month period in which subjects received 1 of 2 diets (diet HP: high protein/low carbohydrate vs. S: standard diet). <b><i>Results:</i></b> One hundred and four patients (54.7%) had the genotype <i>G1359G</i> and 86 (45.3%) patients had <i>G1359A</i> (77 patients, 25.8%) or <i>A1359A</i> (9 patients, 3.7%) (A-allele-carriers). In subjects with both genotypes, the body mass index, weight, fat mass, waist circumference and systolic blood pressures decreased with both diets. After the diet type HP and in subjects with both genotypes, the glucose, leptin, total cholesterol, LDL-cholesterol, insulin and HOMA-R levels decreased. After diet S and in all subjects, the total cholesterol, LDL cholesterol and leptin levels decreased, too. <b><i>Conclusion:</i></b> Our interventional study didn't show a relationship between the rs1049353 CNR-1 polymorphism and body weight response after two different hypocaloric (low carbohydrate/high protein vs. standard) diets over a period of 9 months. However, a low-carbohydrate/high-protein diet for 9 months improved glucose metabolism in subjects with both genotypes." @default.
• W1966746721 created "2016-06-24" @default.
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• W1966746721 date "2015-01-01" @default.
• W1966746721 modified "2023-10-15" @default.
• W1966746721 title "Effects of a High-Protein/Low-Carbohydrate versus a Standard Hypocaloric Diet on Weight and Cardiovascular Risk Factors during 9 Months: Role of a Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A Polymorphism)" @default.
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• W1966746721 doi "https://doi.org/10.1159/000375412" @default.
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