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- W1966752641 endingPage "e1002171" @default.
- W1966752641 startingPage "e1002171" @default.
- W1966752641 abstract "Despite effective chemotherapy to treat schistosome infections, re-infection rates are extremely high. Resistance to reinfection can develop, however it typically takes several years following numerous rounds of treatment and re-infection, and often develops in only a small cohort of individuals. Using a well-established and highly permissive mouse model, we investigated whether immunoregulatory mechanisms influence the development of resistance. Following Praziquantel (PZQ) treatment of S. mansoni infected mice we observed a significant and mixed anti-worm response, characterized by Th1, Th2 and Th17 responses. Despite the elevated anti-worm response in PBMC's, liver, spleen and mesenteric lymph nodes, this did not confer any protection from a secondary challenge infection. Because a significant increase in IL-10-producing CD4+CD44+CD25+GITR+ lymphocytes was observed, we hypothesised that IL-10 was obstructing the development of resistance. Blockade of IL-10 combined with PZQ treatment afforded a greater than 50% reduction in parasite establishment during reinfection, compared to PZQ treatment alone, indicating that IL-10 obstructs the development of acquired resistance. Markedly enhanced Th1, Th2 and Th17 responses, worm-specific IgG1, IgG2b and IgE and circulating eosinophils characterized the protection. This study demonstrates that blocking IL-10 signalling during PZQ treatment can facilitate the development of protective immunity and provide a highly effective strategy to protect against reinfection with S. mansoni." @default.
- W1966752641 created "2016-06-24" @default.
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- W1966752641 creator A5085255411 @default.
- W1966752641 date "2011-08-04" @default.
- W1966752641 modified "2023-10-05" @default.
- W1966752641 title "IL-10 Blocks the Development of Resistance to Re-Infection with Schistosoma mansoni" @default.
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- W1966752641 doi "https://doi.org/10.1371/journal.ppat.1002171" @default.
- W1966752641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3150278" @default.
- W1966752641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21829367" @default.
- W1966752641 hasPublicationYear "2011" @default.
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