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- W1966756382 abstract "The biosynthesis of leukotrienes (LT) C 4 and B 4 is followed by an export of these mediators into the extracellular space. This transport was characterized using plasma membrane vesicles prepared from mastocytoma cells and identified as an ATP‐dependent primary active process. The apparent K m ‐values were 110 nM for LTC 4 and 48 μM for ATP. The transport rate was highest for LTC 4 , whereas LTD 4 , LTE 4 , and N ‐acetyl‐LTE 4 were transported with relative rates of 31, 12 and 8%, respectively, at a concentation of 10nM. LTB 4 transport was also dependent on ATP, LTC 4 transport with inhibited by LTD 4 receptor antagonists (IC 10 = 1.0 μM for MK‐571 and 1.3 μM for LY245769) and by the inhibitor of leukotriene biosynthesis MK‐886 (IC 10 = 1.8 μM). The ATP‐dependent export carrier for leukotrienes in leukotriene‐synthesizing cells represents a novel member of the family of ATP‐dependent exit pumps." @default.
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- W1966756382 date "1991-02-11" @default.
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- W1966756382 title "ATP‐dependent leukotriene export from mastocytoma cells" @default.
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- W1966756382 doi "https://doi.org/10.1016/0014-5793(91)80256-3" @default.
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