FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966761007> ?p ?o ?g. }

• W1966761007 endingPage "362" @default.
• W1966761007 startingPage "354" @default.
• W1966761007 abstract "Isatin (1H-indole-2,3-dione) is a chemical found in various medicinal plant species and responsible for a broad spectrum of pharmacological and biological properties that may be beneficial to human health, as an anticonvulsant, antibacterial, antifungal, antiviral, and anticancer agent. The aim of the present study was to determine in vitro the cytotoxic, mutagenic, and apoptotic effects of isatin on CHO-K1 and HeLa cells using the MTT viability assay (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide), micronucleus (MN) test, apoptosis index, and nuclear division index (NDI). The 5 isatin concentrations evaluated in the mutagenicity and apoptosis tests were 0.5, 1, 5, 10, and 50 μM, selected through a preliminary MTT assay. Positive (doxorubicin, DXR) and negative (phosphate buffered saline, PBS) control groups were also included in the analysis. Isatin did not exert a mutagenic effect on CHO-K1 after 3 and 24 h of treatment or on HeLa cells after 24 h. However, 10 and 50 μM concentrations inhibited cell proliferation and promoted apoptosis in both CHO-K1 and HeLa cells. Data indicate that the cytotoxic, apoptotic, and antiproliferative effects of isatin were concentration independent and cell line independent." @default.
• W1966761007 created "2016-06-24" @default.
• W1966761007 creator A5005798539 @default.
• W1966761007 creator A5005895867 @default.
• W1966761007 creator A5036427375 @default.
• W1966761007 creator A5040883234 @default.
• W1966761007 creator A5061814345 @default.
• W1966761007 creator A5088703650 @default.
• W1966761007 date "2013-03-01" @default.
• W1966761007 modified "2023-10-17" @default.
• W1966761007 title "In Vitro Assessment of the Cytotoxic, Apoptotic, and Mutagenic Potentials of Isatin" @default.
• W1966761007 cites W1964672569 @default.
• W1966761007 cites W1966086881 @default.
• W1966761007 cites W1981900889 @default.
• W1966761007 cites W1986303971 @default.
• W1966761007 cites W1990912266 @default.
• W1966761007 cites W2000618405 @default.
• W1966761007 cites W2002824750 @default.
• W1966761007 cites W2003767043 @default.
• W1966761007 cites W2010761126 @default.
• W1966761007 cites W2018031414 @default.
• W1966761007 cites W2024136343 @default.
• W1966761007 cites W2024264346 @default.
• W1966761007 cites W2025656362 @default.
• W1966761007 cites W2031860793 @default.
• W1966761007 cites W2038956306 @default.
• W1966761007 cites W2041534370 @default.
• W1966761007 cites W2047578735 @default.
• W1966761007 cites W2053794393 @default.
• W1966761007 cites W2056204961 @default.
• W1966761007 cites W2056842005 @default.
• W1966761007 cites W2083477916 @default.
• W1966761007 cites W2085071754 @default.
• W1966761007 cites W2089236884 @default.
• W1966761007 cites W2091932917 @default.
• W1966761007 cites W2098883242 @default.
• W1966761007 cites W2104896140 @default.
• W1966761007 cites W2114918609 @default.
• W1966761007 cites W2122231684 @default.
• W1966761007 cites W2128788119 @default.
• W1966761007 cites W2181449746 @default.
• W1966761007 doi "https://doi.org/10.1080/15287394.2012.755941" @default.
• W1966761007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23557234" @default.
• W1966761007 hasPublicationYear "2013" @default.
• W1966761007 type Work @default.
• W1966761007 sameAs 1966761007 @default.
• W1966761007 citedByCount "13" @default.
• W1966761007 countsByYear W19667610072013 @default.
• W1966761007 countsByYear W19667610072014 @default.
• W1966761007 countsByYear W19667610072015 @default.
• W1966761007 countsByYear W19667610072017 @default.
• W1966761007 countsByYear W19667610072018 @default.
• W1966761007 countsByYear W19667610072020 @default.
• W1966761007 countsByYear W19667610072022 @default.
• W1966761007 crossrefType "journal-article" @default.
• W1966761007 hasAuthorship W1966761007A5005798539 @default.
• W1966761007 hasAuthorship W1966761007A5005895867 @default.
• W1966761007 hasAuthorship W1966761007A5036427375 @default.
• W1966761007 hasAuthorship W1966761007A5040883234 @default.
• W1966761007 hasAuthorship W1966761007A5061814345 @default.
• W1966761007 hasAuthorship W1966761007A5088703650 @default.
• W1966761007 hasConcept C109316439 @default.
• W1966761007 hasConcept C153911025 @default.
• W1966761007 hasConcept C154317977 @default.
• W1966761007 hasConcept C178790620 @default.
• W1966761007 hasConcept C185592680 @default.
• W1966761007 hasConcept C190283241 @default.
• W1966761007 hasConcept C202751555 @default.
• W1966761007 hasConcept C2777256644 @default.
• W1966761007 hasConcept C2777366897 @default.
• W1966761007 hasConcept C2780783641 @default.
• W1966761007 hasConcept C29730261 @default.
• W1966761007 hasConcept C45080847 @default.
• W1966761007 hasConcept C53227056 @default.
• W1966761007 hasConcept C54355233 @default.
• W1966761007 hasConcept C55493867 @default.
• W1966761007 hasConcept C81885089 @default.
• W1966761007 hasConcept C86803240 @default.
• W1966761007 hasConcept C98274493 @default.
• W1966761007 hasConceptScore W1966761007C109316439 @default.
• W1966761007 hasConceptScore W1966761007C153911025 @default.
• W1966761007 hasConceptScore W1966761007C154317977 @default.
• W1966761007 hasConceptScore W1966761007C178790620 @default.
• W1966761007 hasConceptScore W1966761007C185592680 @default.
• W1966761007 hasConceptScore W1966761007C190283241 @default.
• W1966761007 hasConceptScore W1966761007C202751555 @default.
• W1966761007 hasConceptScore W1966761007C2777256644 @default.
• W1966761007 hasConceptScore W1966761007C2777366897 @default.
• W1966761007 hasConceptScore W1966761007C2780783641 @default.
• W1966761007 hasConceptScore W1966761007C29730261 @default.
• W1966761007 hasConceptScore W1966761007C45080847 @default.
• W1966761007 hasConceptScore W1966761007C53227056 @default.
• W1966761007 hasConceptScore W1966761007C54355233 @default.
• W1966761007 hasConceptScore W1966761007C55493867 @default.
• W1966761007 hasConceptScore W1966761007C81885089 @default.
• W1966761007 hasConceptScore W1966761007C86803240 @default.
• W1966761007 hasConceptScore W1966761007C98274493 @default.
• W1966761007 hasIssue "6" @default.

• next