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- W1966763146 abstract "Inflammation has been linked to the initiation and metastatic progression of prostate cancer. We previously reported results showing that CX3CL1 and IL-15 were predominantly down-regulated in prostate cancer patients that develop biochemical recurrence following prostatectomy. This study tests the hypothesis that chemokine biomarkers that predict biochemical recurrence of prostate cancer regulate metastatic progression of the cancer. In order to determine the function of the chemokines, PC3 and LNCaP prostate cancer cell lines were used alone and in combination with conditioned media from prostate stromal cells expressing the chemokines of interest. IL-15 and CX3CL1 cDNAs were subcloned into lentiviral constructs. The lentiviral constructs were transduced into prostate stromal cells developed from wild type C57BL/6 mice. Seventy-two hours conditioned media was used to verify the expression of the respective chemokines by ELISA. The individual prostate cancer cell lines (PC3 and LNCaP) were incubated in the respective stromal conditioned media and characterized for measurable characteristics that promote a cancer cell to be metastatic. In this study we show that IL-15 and CX3CL1 significantly decreased (P Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 391. doi:10.1158/1538-7445.AM2011-391" @default.
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- W1966763146 date "2011-04-15" @default.
- W1966763146 modified "2023-09-26" @default.
- W1966763146 title "Abstract 391: Inflammatory mediators of prostate cancer metastasis" @default.
- W1966763146 doi "https://doi.org/10.1158/1538-7445.am2011-391" @default.
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