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- W1966764648 abstract "Glucagon, secreted by the alpha-cells of the pancreatic islets, is the most important glucose-increasing hormone of the body. The precise regulation of glucagon release remains incompletely defined but has been proposed to involve release of inhibitory factors from neighbouring beta-cells (paracrine control). However, the observation that glucose can regulate glucagon secretion under conditions when insulin secretion does not occur argues that the alpha-cell is also equipped with its own intrinsic (exerted within the alpha-cell itself) glucose sensing. Here we consider the possible mechanisms involved with a focus on ATP-regulated K(+)-channels and changes in alpha-cell membrane potential." @default.
- W1966764648 created "2016-06-24" @default.
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- W1966764648 date "2008-10-01" @default.
- W1966764648 modified "2023-10-16" @default.
- W1966764648 title "KATP-channels and glucose-regulated glucagon secretion" @default.
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- W1966764648 doi "https://doi.org/10.1016/j.tem.2008.07.003" @default.
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