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- W1966774674 abstract "1. 1. Incorporation of 14 C-formate and (2- 14 C)-glycine into nucleic acid bases was studied using normal and regenerating livers of adult rats in vivo and in vitro . The base samples were carefully freed of contaminating amino acids, which may cause serious errors in experiments of this type. 2. 2. Formate and glycine were poorly incorporated into DNA of normal liver, and the specific activity ratio of RNA/DNA for adenine was usually higher than 20, suggesting a remarkable metabolic stability of DNA purines. 3. 3. Incorporation into RNA and acid-soluble purines was relatively inactive in the normal liver in vivo , But was markedly enhanced by partial hepatectomy. 4. 4. In the liver, formate incorporation into nucleic acid purines is not abolished under in vitro conditions or by X-irradiation, but the relative magnitude of the specific activities of adenine, guanine and thymine varied systematically in vivo and in vitro with both precursors." @default.
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- W1966774674 date "1957-01-01" @default.
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- W1966774674 title "Incorporation of 14C-formate and (2-14C)-glycine into nucleic acid bases of the rat liver in vivo and in vitro" @default.
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- W1966774674 doi "https://doi.org/10.1016/0006-3002(57)90532-2" @default.
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