Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966778920> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1966778920 endingPage "288" @default.
- W1966778920 startingPage "283" @default.
- W1966778920 abstract "BALB/c mice were chronically and unilaterally implanted with a guide cannula, the tip of which was positioned 1 mm above the lateral hypothalamus (LH). On each experimental day, a stainless-steel injection cannula was inserted into the LH, and self-administration of morphine or vehicle in this brain area was studied by using a spatial discrimination test in a Y-maze. In a first experiment, we observed that when mice had access to morphine (0.1 microgram by injection) they rapidly discriminated the reinforced arm from the neutral arm of the maze in order to self administer, with increasing frequency, the drug into the LH. In contrast when only vehicle was present, the two arms were no longer discriminated. In a second experiment we compared the effects of 3 doses of morphine (0.1 microgram, 0.05 microgram and 0.025 microgram by injection); optimal discrimination was obtained with the lowest dose used. In a third experiment we observed that subcutaneous injections of naloxone (4 mg/kg) progressively reduced the number of self-administrations of morphine into the LH, a result which suggests that this response is dependent on an opiate receptor mechanism." @default.
- W1966778920 created "2016-06-24" @default.
- W1966778920 creator A5039719834 @default.
- W1966778920 creator A5046610085 @default.
- W1966778920 creator A5055468544 @default.
- W1966778920 date "1987-07-01" @default.
- W1966778920 modified "2023-09-27" @default.
- W1966778920 title "Self-administration of morphine into the lateral hypothalamus in the mouse" @default.
- W1966778920 cites W1979684634 @default.
- W1966778920 cites W1984153476 @default.
- W1966778920 cites W2000009623 @default.
- W1966778920 cites W2040132819 @default.
- W1966778920 cites W2070316919 @default.
- W1966778920 cites W2078551540 @default.
- W1966778920 cites W2084024177 @default.
- W1966778920 doi "https://doi.org/10.1016/0006-8993(87)90908-5" @default.
- W1966778920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3620961" @default.
- W1966778920 hasPublicationYear "1987" @default.
- W1966778920 type Work @default.
- W1966778920 sameAs 1966778920 @default.
- W1966778920 citedByCount "51" @default.
- W1966778920 countsByYear W19667789202012 @default.
- W1966778920 countsByYear W19667789202013 @default.
- W1966778920 countsByYear W19667789202014 @default.
- W1966778920 countsByYear W19667789202015 @default.
- W1966778920 countsByYear W19667789202016 @default.
- W1966778920 countsByYear W19667789202020 @default.
- W1966778920 countsByYear W19667789202021 @default.
- W1966778920 countsByYear W19667789202023 @default.
- W1966778920 crossrefType "journal-article" @default.
- W1966778920 hasAuthorship W1966778920A5039719834 @default.
- W1966778920 hasAuthorship W1966778920A5046610085 @default.
- W1966778920 hasAuthorship W1966778920A5055468544 @default.
- W1966778920 hasConcept C126322002 @default.
- W1966778920 hasConcept C134018914 @default.
- W1966778920 hasConcept C141071460 @default.
- W1966778920 hasConcept C170493617 @default.
- W1966778920 hasConcept C185592680 @default.
- W1966778920 hasConcept C202751555 @default.
- W1966778920 hasConcept C2776390293 @default.
- W1966778920 hasConcept C2777003273 @default.
- W1966778920 hasConcept C2777389121 @default.
- W1966778920 hasConcept C2778074680 @default.
- W1966778920 hasConcept C2778140631 @default.
- W1966778920 hasConcept C2778750930 @default.
- W1966778920 hasConcept C2781063702 @default.
- W1966778920 hasConcept C42219234 @default.
- W1966778920 hasConcept C51296783 @default.
- W1966778920 hasConcept C55493867 @default.
- W1966778920 hasConcept C71924100 @default.
- W1966778920 hasConceptScore W1966778920C126322002 @default.
- W1966778920 hasConceptScore W1966778920C134018914 @default.
- W1966778920 hasConceptScore W1966778920C141071460 @default.
- W1966778920 hasConceptScore W1966778920C170493617 @default.
- W1966778920 hasConceptScore W1966778920C185592680 @default.
- W1966778920 hasConceptScore W1966778920C202751555 @default.
- W1966778920 hasConceptScore W1966778920C2776390293 @default.
- W1966778920 hasConceptScore W1966778920C2777003273 @default.
- W1966778920 hasConceptScore W1966778920C2777389121 @default.
- W1966778920 hasConceptScore W1966778920C2778074680 @default.
- W1966778920 hasConceptScore W1966778920C2778140631 @default.
- W1966778920 hasConceptScore W1966778920C2778750930 @default.
- W1966778920 hasConceptScore W1966778920C2781063702 @default.
- W1966778920 hasConceptScore W1966778920C42219234 @default.
- W1966778920 hasConceptScore W1966778920C51296783 @default.
- W1966778920 hasConceptScore W1966778920C55493867 @default.
- W1966778920 hasConceptScore W1966778920C71924100 @default.
- W1966778920 hasIssue "2" @default.
- W1966778920 hasLocation W19667789201 @default.
- W1966778920 hasLocation W19667789202 @default.
- W1966778920 hasOpenAccess W1966778920 @default.
- W1966778920 hasPrimaryLocation W19667789201 @default.
- W1966778920 hasRelatedWork W1966015575 @default.
- W1966778920 hasRelatedWork W1972293054 @default.
- W1966778920 hasRelatedWork W2029486896 @default.
- W1966778920 hasRelatedWork W2042834119 @default.
- W1966778920 hasRelatedWork W2060367584 @default.
- W1966778920 hasRelatedWork W2065171205 @default.
- W1966778920 hasRelatedWork W2066074728 @default.
- W1966778920 hasRelatedWork W2078741875 @default.
- W1966778920 hasRelatedWork W2145845730 @default.
- W1966778920 hasRelatedWork W2748952813 @default.
- W1966778920 hasVolume "416" @default.
- W1966778920 isParatext "false" @default.
- W1966778920 isRetracted "false" @default.
- W1966778920 magId "1966778920" @default.
- W1966778920 workType "article" @default.