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• W1966793802 abstract "The lateral hypothalamus is a brain region historically implicated in reward and motivation, but the identity of the neurotransmitters involved are unknown. The orexins (or hypocretins) are neuropeptides recently identified as neurotransmitters in lateral hypothalamus neurons. Although knockout and transgenic overexpression studies have implicated orexin neurons in arousal and sleep, these cells also project to reward-associated brain regions, including the nucleus accumbens and ventral tegmental area. This indicates a possible role for these neurons in reward function and motivation, consistent with previous studies implicating these neurons in feeding. Here we show that activation of lateral hypothalamus orexin neurons is strongly linked to preferences for cues associated with drug and food reward. In addition, we show that chemical activation of lateral hypothalamus orexin neurons reinstates an extinguished drug-seeking behaviour. This reinstatement effect was completely blocked by prior administration of an orexin A antagonist. Moreover, administration of the orexin A peptide directly into the ventral tegmental area also reinstated drug-seeking. These data reveal a new role for lateral hypothalamus orexin neurons in reward-seeking, drug relapse and addiction." @default.
• W1966793802 created "2016-06-24" @default.
• W1966793802 creator A5025687682 @default.
• W1966793802 creator A5030113568 @default.
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• W1966793802 date "2005-08-14" @default.
• W1966793802 modified "2023-10-10" @default.
• W1966793802 title "A role for lateral hypothalamic orexin neurons in reward seeking" @default.
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• W1966793802 doi "https://doi.org/10.1038/nature04071" @default.
• W1966793802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16100511" @default.
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