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- W1966795295 abstract "Structural modification of steroids through whole-cell biocatalysis is an invaluable procedure for the production of active pharmaceutical ingredients (APIs) and key intermediates. Modifications could be carried out with regio- and stereospecificity at positions hardly available for chemical agents. Much attention has been focused recently on the biotransformation of 17α-ethynyl substituted steroidal drugs using fungi, bacteria and plant cell cultures in order to obtained novel biologically active compounds with diverse structure features. Present article includes studies on biotransformation on 17α-ethynyl substituted steroidal drugs using microorganisms and plant cell cultures. Various experimental and structural elucidation methods used in biotransformational processes are also highlighted." @default.
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- W1966795295 date "2013-12-01" @default.
- W1966795295 modified "2023-09-26" @default.
- W1966795295 title "Biotransformation of 17α-ethynyl substituted steroidal drugs with microbial and plant cell cultures: A review" @default.
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- W1966795295 doi "https://doi.org/10.1016/j.steroids.2013.10.001" @default.
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