Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966796321> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1966796321 abstract "Multiparameter phenotypic profiling has emerged as a powerful tool for characterizing small molecules and their effects on complex biological systems. In particular, the union of high-throughput screening technologies with automated microscopy and image processing has enabled the development of multiparameter image-based profiling techniques (also called “cytological profiling”), in which cells are imaged in multiwell plate format using automated fluorescence microscopy and the resulting images are quantified in terms of various descriptors, or “features.” Rather than focusing on a specific phenotype or biological endpoint, CP strategies employ multiple cytological probes that are selected to cover a wide range of biological pathways. Although CP has been used successfully to classify diverse bioactive compounds, its application in the area of natural products (NP) discovery has been limited. Here we describe the use of cytological profiling to discover natural products with novel mechanisms of action (MOAs). The goal of this project is to invert the NP discovery process from the traditional approach, where compound identification and function are the final steps in the discovery process, to a new paradigm where identities and functions of active constituents are determined directly from primary screening data and lead compounds are selected based on chemical and biological novelty prior to isolation and full structural characterization. Futhermore, the integration of CP fingerprints with metabolomics data allows us to rapidly associate compounds with phenotypes and prioritize unique chemistries for follow up. Citation Format: Scott M. Lokey. Accelerating natural product discovery with multivariate image-based screening [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr IA2." @default.
- W1966796321 created "2016-06-24" @default.
- W1966796321 creator A5079591459 @default.
- W1966796321 date "2012-07-01" @default.
- W1966796321 modified "2023-10-14" @default.
- W1966796321 title "Abstract IA2: Accelerating natural product discovery with multivariate image-based screening" @default.
- W1966796321 doi "https://doi.org/10.1158/1538-7445.csb12-ia2" @default.
- W1966796321 hasPublicationYear "2012" @default.
- W1966796321 type Work @default.
- W1966796321 sameAs 1966796321 @default.
- W1966796321 citedByCount "0" @default.
- W1966796321 crossrefType "proceedings-article" @default.
- W1966796321 hasAuthorship W1966796321A5079591459 @default.
- W1966796321 hasConcept C104317684 @default.
- W1966796321 hasConcept C111919701 @default.
- W1966796321 hasConcept C124101348 @default.
- W1966796321 hasConcept C127716648 @default.
- W1966796321 hasConcept C1491633281 @default.
- W1966796321 hasConcept C153180895 @default.
- W1966796321 hasConcept C154945302 @default.
- W1966796321 hasConcept C157044486 @default.
- W1966796321 hasConcept C187191949 @default.
- W1966796321 hasConcept C2779396153 @default.
- W1966796321 hasConcept C41008148 @default.
- W1966796321 hasConcept C51323132 @default.
- W1966796321 hasConcept C54355233 @default.
- W1966796321 hasConcept C55493867 @default.
- W1966796321 hasConcept C60644358 @default.
- W1966796321 hasConcept C6555983 @default.
- W1966796321 hasConcept C70721500 @default.
- W1966796321 hasConcept C74187038 @default.
- W1966796321 hasConcept C86803240 @default.
- W1966796321 hasConceptScore W1966796321C104317684 @default.
- W1966796321 hasConceptScore W1966796321C111919701 @default.
- W1966796321 hasConceptScore W1966796321C124101348 @default.
- W1966796321 hasConceptScore W1966796321C127716648 @default.
- W1966796321 hasConceptScore W1966796321C1491633281 @default.
- W1966796321 hasConceptScore W1966796321C153180895 @default.
- W1966796321 hasConceptScore W1966796321C154945302 @default.
- W1966796321 hasConceptScore W1966796321C157044486 @default.
- W1966796321 hasConceptScore W1966796321C187191949 @default.
- W1966796321 hasConceptScore W1966796321C2779396153 @default.
- W1966796321 hasConceptScore W1966796321C41008148 @default.
- W1966796321 hasConceptScore W1966796321C51323132 @default.
- W1966796321 hasConceptScore W1966796321C54355233 @default.
- W1966796321 hasConceptScore W1966796321C55493867 @default.
- W1966796321 hasConceptScore W1966796321C60644358 @default.
- W1966796321 hasConceptScore W1966796321C6555983 @default.
- W1966796321 hasConceptScore W1966796321C70721500 @default.
- W1966796321 hasConceptScore W1966796321C74187038 @default.
- W1966796321 hasConceptScore W1966796321C86803240 @default.
- W1966796321 hasLocation W19667963211 @default.
- W1966796321 hasOpenAccess W1966796321 @default.
- W1966796321 hasPrimaryLocation W19667963211 @default.
- W1966796321 hasRelatedWork W1573446871 @default.
- W1966796321 hasRelatedWork W1976668183 @default.
- W1966796321 hasRelatedWork W1983601761 @default.
- W1966796321 hasRelatedWork W2017757915 @default.
- W1966796321 hasRelatedWork W2025846584 @default.
- W1966796321 hasRelatedWork W2060049549 @default.
- W1966796321 hasRelatedWork W2145021813 @default.
- W1966796321 hasRelatedWork W2148857874 @default.
- W1966796321 hasRelatedWork W2160676466 @default.
- W1966796321 hasRelatedWork W2187948137 @default.
- W1966796321 hasRelatedWork W2301751010 @default.
- W1966796321 hasRelatedWork W2794334542 @default.
- W1966796321 hasRelatedWork W2799644139 @default.
- W1966796321 hasRelatedWork W2807829222 @default.
- W1966796321 hasRelatedWork W2811066512 @default.
- W1966796321 hasRelatedWork W2968968218 @default.
- W1966796321 hasRelatedWork W2971653625 @default.
- W1966796321 hasRelatedWork W3112295230 @default.
- W1966796321 hasRelatedWork W3201368943 @default.
- W1966796321 hasRelatedWork W3201618068 @default.
- W1966796321 isParatext "false" @default.
- W1966796321 isRetracted "false" @default.
- W1966796321 magId "1966796321" @default.
- W1966796321 workType "article" @default.