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• W1966796558 endingPage "e1000562" @default.
• W1966796558 startingPage "e1000562" @default.
• W1966796558 abstract "It has not previously been possible to live image the earliest interactions between the host environment and oncogene-transformed cells as they initiate formation of cancers within an organism. Here we take advantage of the translucency of zebrafish larvae to observe the host innate immune cell response as oncogene-transformed melanoblasts and goblet cells multiply within the larval skin. Our studies indicate activation of leukocytes at very early stages in larvae carrying a transformed cell burden. Locally, we see recruitment of neutrophils and macrophages by 48 h post-fertilization, when transformed cells are still only singletons or doublets, and soon after this we see intimate associations between immune and transformed cells and frequent examples of cytoplasmic tethers linking the two cell types, as well as engulfment of transformed cells by both neutrophils and macrophages. We show that a major component of the signal drawing inflammatory cells to oncogenic HRASG12V-transformed cells is H2O2, which is also a key damage cue responsible for recruiting neutrophils to a wound. Our short-term blocking experiments show that preventing recruitment of immune cells at these early stages results in reduced growth of transformed cell clones and suggests that immune cells may provide a source of trophic support to the transformed cells just as they do at a site of tissue repair. These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds." @default.
• W1966796558 created "2016-06-24" @default.
• W1966796558 creator A5014597227 @default.
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• W1966796558 creator A5062104763 @default.
• W1966796558 creator A5081036799 @default.
• W1966796558 date "2010-12-14" @default.
• W1966796558 modified "2023-10-05" @default.
• W1966796558 title "Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation" @default.
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• W1966796558 doi "https://doi.org/10.1371/journal.pbio.1000562" @default.
• W1966796558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4750939" @default.
• W1966796558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26866370" @default.
• W1966796558 hasPublicationYear "2010" @default.
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