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- W1966796616 abstract "The HLA class Ib antigen, HLA-G, is highly expressed in early gestation placentas where it is believed to modulate maternal-fetal immunological interactions. In this study, soluble isoforms (sHLA-G) encoded by intron 4-retaining transcripts were identified in first trimester placentas by immunohistochemistry using a mAb specific for the C-terminus of sHLA-G. Immunoreactive sHLA-G protein was localized to trophoblast cells and to villous mesenchymal cells with the morphological features of macrophages. Reverse transcriptase polymerase chain reaction analysis which used primers specific for intron 4 and the 3′ untranslated region of the HLA-G gene showed that transcripts encoding sHLA-G were present in the trophoblast-derived Jeg-3 cells as well as interferon-γ-activated myelomonocytic U937 cells but were absent and uninducible in placental fibroblasts. These results indicate that placental sHLA-G is synthesized in trophoblast cells and activated placental macrophages and support the postulate that placenta-derived sHLA-G modulates maternal and fetal immune cell functions during pregnancy." @default.
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- W1966796616 date "1998-07-01" @default.
- W1966796616 modified "2023-10-18" @default.
- W1966796616 title "Soluble HLA-G in Human Placentas: Synthesis in Trophoblasts and Interferon-γ-Activated Macrophages But Not Placental Fibroblasts" @default.
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- W1966796616 doi "https://doi.org/10.1016/s0198-8859(98)00045-7" @default.
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