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• W1966802693 abstract "We have investigated the effects of intracerebroventricular injections of angiotensin II in conscious rats on the expression of c-fos messenger RNA (mRNA) in the caudate nucleus, hypothalamus, midbrain and brainstem using semi-quantitative polymerase chain reaction and Northern Blots. RNA analysis revealed the presence of c-fos transcripts in the midbrain and brainstem following icv injections of ANG II. ANG II (1, 10, 100 ng) induced a substantial increase in c-fos mRNA in the brainstem which was significant after 10 ng ANG II, and less after 100 ng. This effect was time-dependent being detectable within 15 minutes and maximal after 60 minutes. This ANG II-induced c-fos mRNA expression was totally inhibited by icv pretreatment with the ANG II-AT1 receptor antagonist, losartan. Our data show for the first time that stimulation of central periventricular AT1 receptors induces the expression of c-fos mRNA in the brain. Thus, ANG II, in addition to its short-term regulatory actions, can participate through transcription factors in neuroplastic processes." @default.
• W1966802693 created "2016-06-24" @default.
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• W1966802693 date "1995-01-01" @default.
• W1966802693 modified "2023-09-23" @default.
• W1966802693 title "Angiotensin II Induces the Expression of C-FOS mRNA in the Central Nervous System of the Rat" @default.
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• W1966802693 doi "https://doi.org/10.3109/10641969509033641" @default.
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