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• W1966804925 abstract "Increased levels of tau and decreased levels of Aβ42 in cerebrospinal fluid (CSF) have high sensitivity and specificity for diagnosing Alzheimer's disease (AD). In addition, a combined measure of Aβ42 and tau phosphorylated at threonine 181 (p-tau181) has a high predictive value to identify subjects with mild cognitive impairment (MCI) that will progress to AD. Moreover, MCI subjects with the APOEϵ4 allele are more likely than non-ϵ4 carriers to progress to AD. Lumbar puncture was performed on 58 MCI patients between 1993 and 2001. The CSF samples had been stored in -80 and were now analyzed for Aβ42, total tau and p-tau181. For comparison, AD patients (n=57) and non-neurological control (n=45) subjects were included. Moreover, all groups were designed so that the APOE genotypes ϵ3/ϵ3, ϵ3/ϵ4 and ϵ4/ϵ4 were represented. During a twelve year follow-up period, 48% (n=28) of the individuals in the MCI group were re-examined on one or several occasions (9 ϵ3/ϵ3, 10 ϵ3/ϵ4, 8 ϵ4/ϵ4, 1 unknown APOE genotype). AD patients had the highest levels of total tau and p-tau181 along with the lowest levels of Aβ42 in CSF. Subjects with MCI displayed higher total tau than controls (p<0.05), whereas they did not differ in Aβ42 levels. In the MCI group, half (n=14) of the re-examined patients progressed to AD during an average of 3.4 ± 2.1 years whereas the other half (n=14) remained as MCI for an average period of 5.6 ± 2.7 years. The progressors had higher baseline levels of CSF total tau and p-tau181, whereas they did not differ in CSF Aβ42 levels. Furthermore, seven of the progressors were APOE ϵ4/ϵ4, three APOE ϵ3/ϵ4, three APOE ϵ3/ϵ3 and one had an unknown APOE genotype. Only one MCI subject with APOE ϵ4/ϵ4 did not progress to AD. Our data support an increased risk for conversion from MCI to AD among subjects with high CSF levels of total tau and p-tau181, whereas we did not find that CSF Aβ42 alone was predicting conversion. Finally, we could in this cohort corroborate that the APOE ϵ4/ϵ4 genotype predicts future progression from MCI to AD." @default.
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• W1966804925 date "2008-07-01" @default.
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• W1966804925 title "P3-076: CSF Tau levels and APOEϵ4 carriership predict the progression of mild cognitive impairment to Alzheimer's disease" @default.
• W1966804925 doi "https://doi.org/10.1016/j.jalz.2008.05.1640" @default.
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