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• W1966809042 abstract "Activation of naive T cells is tightly controlled and depends on cognate interactions with professional antigen-presenting cells. We analyzed dependency on secondary lymphoid tissues for the activation of naive and memory CD4+ and CD8+ T cells following primary and secondary Listeria monocytogenes infection, respectively. In splenectomized lymphotoxin-β receptor-deficient mice, lacking all secondary lymphoid tissues, oral infection with L. monocytogenes failed to induce bacteria-specific CD4+ and CD8+ T cell responses. Treatment of splenectomized wild-type mice with FTY720, a drug that prevents egress of T cells from lymph nodes, also reduced T cell responses after oral L. monocytogenes infection and blocked T cell responses after intravenous infection. FTY720-treated wild-type and lymphotoxin-β receptor-deficient mice show only slightly impaired recall responses. However, T cell responses were profoundly inhibited when mice were splenectomized subsequently to recovery from primary infection. T cell transfer experiments demonstrated that the impaired secondary T cell response was not simply due to removal of a large fraction of memory T cells by splenectomy. Overall, these results indicate that not only primary T cell responses, but also secondary T cell responses, highly depend on the lymphoid environment for effective activation." @default.
• W1966809042 created "2016-06-24" @default.
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• W1966809042 date "2008-01-01" @default.
• W1966809042 modified "2023-09-26" @default.
• W1966809042 title "Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses againstListeria monocytogenes" @default.
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• W1966809042 doi "https://doi.org/10.1002/eji.200737142" @default.
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