FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966811293> ?p ?o ?g. }

• W1966811293 endingPage "2215" @default.
• W1966811293 startingPage "2206" @default.
• W1966811293 abstract "The endophytic fungus Pestalotiopsis virgatula, derived from the plant Terminalia chebula and previously found to produce a large excess of a single metabolite when grown in the minimal M1D medium, was induced to produce a variety of unusual metabolites by growing in potato dextrose broth medium. Analysis of the fermentation medium extract was performed using an HPLC-PDA-MS-SPE-NMR hyphenated system, which led to the identification of a total of eight metabolites (1-8), six of which are new. Most of the metabolites are structurally related and are derivatives of benzo[c]oxepin, rare among natural products. This includes dispiro derivatives 7 and 8 (pestalospiranes A and B), having a novel 1,9,11,18-tetraoxadispiro[6.2.6.2]octadecane skeleton. Relative and absolute configurations of the latter were determined by a combination of NOESY spectroscopy and electronic circular dichroism spectroscopy supported by time-dependent density-functional theory calculations (B3LYP/TZVP level). This work demonstrates that a largely complete structure elucidation of numerous metabolites present in a raw fermentation medium extract can be performed by the HPLC-SPE-NMR technique using only a small amount of the extract, even with unstable metabolites that are difficult to isolate by traditional methods." @default.
• W1966811293 created "2016-06-24" @default.
• W1966811293 creator A5002139604 @default.
• W1966811293 creator A5009900068 @default.
• W1966811293 creator A5034608793 @default.
• W1966811293 creator A5050648992 @default.
• W1966811293 creator A5054738984 @default.
• W1966811293 creator A5057606886 @default.
• W1966811293 creator A5066539032 @default.
• W1966811293 date "2011-09-26" @default.
• W1966811293 modified "2023-09-27" @default.
• W1966811293 title "Production of Unusual Dispiro Metabolites in<i>Pestalotiopsis virgatula</i>Endophyte Cultures: HPLC-SPE-NMR, Electronic Circular Dichroism, and Time-Dependent Density-Functional Computation Study" @default.
• W1966811293 cites W1795273528 @default.
• W1966811293 cites W1963683620 @default.
• W1966811293 cites W1966180937 @default.
• W1966811293 cites W1978405540 @default.
• W1966811293 cites W1985327388 @default.
• W1966811293 cites W1986723974 @default.
• W1966811293 cites W1988895859 @default.
• W1966811293 cites W1992446742 @default.
• W1966811293 cites W1993117101 @default.
• W1966811293 cites W2011044228 @default.
• W1966811293 cites W2011468738 @default.
• W1966811293 cites W2011871839 @default.
• W1966811293 cites W2012037242 @default.
• W1966811293 cites W2023271753 @default.
• W1966811293 cites W2023472900 @default.
• W1966811293 cites W2028022118 @default.
• W1966811293 cites W2028240560 @default.
• W1966811293 cites W2028573971 @default.
• W1966811293 cites W2029261546 @default.
• W1966811293 cites W2032529064 @default.
• W1966811293 cites W2034080226 @default.
• W1966811293 cites W2035964109 @default.
• W1966811293 cites W2042222637 @default.
• W1966811293 cites W2043050460 @default.
• W1966811293 cites W2043098254 @default.
• W1966811293 cites W2043289059 @default.
• W1966811293 cites W2045589580 @default.
• W1966811293 cites W2052727656 @default.
• W1966811293 cites W2053001524 @default.
• W1966811293 cites W2054883348 @default.
• W1966811293 cites W2056557733 @default.
• W1966811293 cites W2058210956 @default.
• W1966811293 cites W2067046930 @default.
• W1966811293 cites W2067207141 @default.
• W1966811293 cites W2068223321 @default.
• W1966811293 cites W2069807850 @default.
• W1966811293 cites W2074404033 @default.
• W1966811293 cites W2075496629 @default.
• W1966811293 cites W2076791051 @default.
• W1966811293 cites W2078146328 @default.
• W1966811293 cites W2086957099 @default.
• W1966811293 cites W2119084078 @default.
• W1966811293 cites W2120763351 @default.
• W1966811293 cites W2123697951 @default.
• W1966811293 cites W2125871258 @default.
• W1966811293 cites W2143981217 @default.
• W1966811293 cites W2150669502 @default.
• W1966811293 cites W2318190710 @default.
• W1966811293 cites W2811241490 @default.
• W1966811293 cites W2952546779 @default.
• W1966811293 cites W2953059452 @default.
• W1966811293 cites W2005178362 @default.
• W1966811293 doi "https://doi.org/10.1021/np2005665" @default.
• W1966811293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21942847" @default.
• W1966811293 hasPublicationYear "2011" @default.
• W1966811293 type Work @default.
• W1966811293 sameAs 1966811293 @default.
• W1966811293 citedByCount "36" @default.
• W1966811293 countsByYear W19668112932012 @default.
• W1966811293 countsByYear W19668112932013 @default.
• W1966811293 countsByYear W19668112932014 @default.
• W1966811293 countsByYear W19668112932015 @default.
• W1966811293 countsByYear W19668112932016 @default.
• W1966811293 countsByYear W19668112932017 @default.
• W1966811293 countsByYear W19668112932018 @default.
• W1966811293 countsByYear W19668112932019 @default.
• W1966811293 countsByYear W19668112932020 @default.
• W1966811293 countsByYear W19668112932021 @default.
• W1966811293 countsByYear W19668112932022 @default.
• W1966811293 crossrefType "journal-article" @default.
• W1966811293 hasAuthorship W1966811293A5002139604 @default.
• W1966811293 hasAuthorship W1966811293A5009900068 @default.
• W1966811293 hasAuthorship W1966811293A5034608793 @default.
• W1966811293 hasAuthorship W1966811293A5050648992 @default.
• W1966811293 hasAuthorship W1966811293A5054738984 @default.
• W1966811293 hasAuthorship W1966811293A5057606886 @default.
• W1966811293 hasAuthorship W1966811293A5066539032 @default.
• W1966811293 hasConcept C100544194 @default.
• W1966811293 hasConcept C121332964 @default.
• W1966811293 hasConcept C133571119 @default.
• W1966811293 hasConcept C178790620 @default.
• W1966811293 hasConcept C179998833 @default.
• W1966811293 hasConcept C185592680 @default.
• W1966811293 hasConcept C19549132 @default.
• W1966811293 hasConcept C2777477808 @default.
• W1966811293 hasConcept C32891209 @default.

• next