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- W1966821331 endingPage "387" @default.
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- W1966821331 abstract "Physiologically based pharmacokinetic (PBPK) models are built using differential equations to describe the physiology/anatomy of different biological systems. Readily available in vitro and in vivo preclinical data can be incorporated into these models to not only estimate pharmacokinetic (PK) parameters and plasma concentration–time profiles, but also to gain mechanistic insight into compound properties. They provide a mechanistic framework to understand and extrapolate PK and dose across in vitro and in vivo systems and across different species, populations and disease states. Using small molecule and large molecule examples from the literature and our own company, we have shown how PBPK techniques can be utilised for human PK and dose prediction. Such approaches have the potential to increase efficiency, reduce the need for animal studies, replace clinical trials and increase PK understanding. Given the mechanistic nature of these models, the future use of PBPK modelling in drug discovery and development is promising, however some limitations need to be addressed to realise its application and utility more broadly." @default.
- W1966821331 created "2016-06-24" @default.
- W1966821331 creator A5016745322 @default.
- W1966821331 creator A5051609996 @default.
- W1966821331 creator A5055746516 @default.
- W1966821331 date "2012-12-27" @default.
- W1966821331 modified "2023-10-03" @default.
- W1966821331 title "Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches" @default.
- W1966821331 cites W1500554051 @default.
- W1966821331 cites W1505675852 @default.
- W1966821331 cites W1505676752 @default.
- W1966821331 cites W1547437295 @default.
- W1966821331 cites W1549457774 @default.
- W1966821331 cites W1928409188 @default.
- W1966821331 cites W1964156098 @default.
- W1966821331 cites W1964935486 @default.
- W1966821331 cites W1966465047 @default.
- W1966821331 cites W1968101595 @default.
- W1966821331 cites W1968191029 @default.
- W1966821331 cites W1970875728 @default.
- W1966821331 cites W1971263174 @default.
- W1966821331 cites W1972328515 @default.
- W1966821331 cites W1978655276 @default.
- W1966821331 cites W1979264461 @default.
- W1966821331 cites W1984452104 @default.
- W1966821331 cites W1987574056 @default.
- W1966821331 cites W1990762022 @default.
- W1966821331 cites W1990804549 @default.
- W1966821331 cites W1991512646 @default.
- W1966821331 cites W1994627863 @default.
- W1966821331 cites W1998103666 @default.
- W1966821331 cites W2002765161 @default.
- W1966821331 cites W2006967678 @default.
- W1966821331 cites W2006974408 @default.
- W1966821331 cites W2009316291 @default.
- W1966821331 cites W2010152279 @default.
- W1966821331 cites W2011901923 @default.
- W1966821331 cites W2013258146 @default.
- W1966821331 cites W2016167200 @default.
- W1966821331 cites W2017983838 @default.
- W1966821331 cites W2021872392 @default.
- W1966821331 cites W2026015795 @default.
- W1966821331 cites W2028165836 @default.
- W1966821331 cites W2029590089 @default.
- W1966821331 cites W2030475758 @default.
- W1966821331 cites W2031426306 @default.
- W1966821331 cites W2031652509 @default.
- W1966821331 cites W2039144093 @default.
- W1966821331 cites W2039250788 @default.
- W1966821331 cites W2040233060 @default.
- W1966821331 cites W2041777107 @default.
- W1966821331 cites W2042196165 @default.
- W1966821331 cites W2042446520 @default.
- W1966821331 cites W2042766684 @default.
- W1966821331 cites W2050819978 @default.
- W1966821331 cites W2051674641 @default.
- W1966821331 cites W2054939724 @default.
- W1966821331 cites W2056439160 @default.
- W1966821331 cites W2062826169 @default.
- W1966821331 cites W2064799851 @default.
- W1966821331 cites W2067600528 @default.
- W1966821331 cites W2067933166 @default.
- W1966821331 cites W2070764085 @default.
- W1966821331 cites W2071694194 @default.
- W1966821331 cites W2071843728 @default.
- W1966821331 cites W2074689515 @default.
- W1966821331 cites W2075577306 @default.
- W1966821331 cites W2077984371 @default.
- W1966821331 cites W2080335269 @default.
- W1966821331 cites W2087759076 @default.
- W1966821331 cites W2093733494 @default.
- W1966821331 cites W2095810566 @default.
- W1966821331 cites W2099086608 @default.
- W1966821331 cites W2099089564 @default.
- W1966821331 cites W2100793130 @default.
- W1966821331 cites W2105114886 @default.
- W1966821331 cites W2107571168 @default.
- W1966821331 cites W2109530280 @default.
- W1966821331 cites W2115714615 @default.
- W1966821331 cites W2120152745 @default.
- W1966821331 cites W2120398079 @default.
- W1966821331 cites W2123119702 @default.
- W1966821331 cites W2128711865 @default.
- W1966821331 cites W2128897405 @default.
- W1966821331 cites W2134794720 @default.
- W1966821331 cites W2135772015 @default.
- W1966821331 cites W2136646559 @default.
- W1966821331 cites W2140204532 @default.
- W1966821331 cites W2144030667 @default.
- W1966821331 cites W2145533061 @default.
- W1966821331 cites W2146393360 @default.
- W1966821331 cites W2148925220 @default.
- W1966821331 cites W2149429360 @default.
- W1966821331 cites W2150060563 @default.
- W1966821331 cites W2151568835 @default.
- W1966821331 cites W2153728590 @default.
- W1966821331 cites W2156445661 @default.
- W1966821331 cites W2157772258 @default.