FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966822023> ?p ?o ?g. }

• W1966822023 endingPage "927" @default.
• W1966822023 startingPage "920" @default.
• W1966822023 abstract "Vaccines formulated with the Chlamydia muridarum native major outer membrane protein (nMOMP) have so far been shown to elicit the most robust protection against this pathogen. nMOMP is a membrane protein and therefore, detergents are used to keep it in solution. Detergents however, have toxic effects. To address this limitation, we tested a nMOMP proteosome vaccine and compared its ability to elicit protection against nMOMP solubilized in the detergent Z3-14. The two preparations were formulated with or without CpG + Montanide (C/M). As a control antigen we used ovalbumin. Mice vaccinated with nMOMP developed strong humoral and cell mediated Chlamydia-specific immune responses. Based on the IgG2a/IgG1 levels in serum and amounts of IFN-γ in splenocytes supernatants the immune responses were predominantly Th1-biased. The animals were subsequently challenged intranasally with 2 × 103 Chlamydia inclusion forming units (IFU) and the course of the infection was followed for 10 days when the mice were euthanized. Based on changes in body weight, weight of the lungs and number of IFU recovered from the lungs, mice immunized with nMOMP-Ps and nMOMP + Z3-14 adjuvanted with C/M showed the most robust protection. In summary, nMOMP-Ps should be considered as Chlamydia vaccine candidates." @default.
• W1966822023 created "2016-06-24" @default.
• W1966822023 creator A5020480735 @default.
• W1966822023 creator A5030088742 @default.
• W1966822023 creator A5035568455 @default.
• W1966822023 creator A5075449858 @default.
• W1966822023 creator A5079409467 @default.
• W1966822023 date "2013-11-01" @default.
• W1966822023 modified "2023-10-18" @default.
• W1966822023 title "Vaccination with major outer membrane protein proteosomes elicits protection in mice against a Chlamydia respiratory challenge" @default.
• W1966822023 cites W1524799490 @default.
• W1966822023 cites W1751602369 @default.
• W1966822023 cites W1971659604 @default.
• W1966822023 cites W1988208510 @default.
• W1966822023 cites W1994308385 @default.
• W1966822023 cites W2002568336 @default.
• W1966822023 cites W2007525636 @default.
• W1966822023 cites W2018855654 @default.
• W1966822023 cites W2027322809 @default.
• W1966822023 cites W2027508983 @default.
• W1966822023 cites W2028079049 @default.
• W1966822023 cites W2029772952 @default.
• W1966822023 cites W2040455921 @default.
• W1966822023 cites W2040626353 @default.
• W1966822023 cites W2041440446 @default.
• W1966822023 cites W2047761722 @default.
• W1966822023 cites W2054920920 @default.
• W1966822023 cites W2058848793 @default.
• W1966822023 cites W2061203889 @default.
• W1966822023 cites W2087961202 @default.
• W1966822023 cites W2095403381 @default.
• W1966822023 cites W2104286735 @default.
• W1966822023 cites W2107760448 @default.
• W1966822023 cites W2108098013 @default.
• W1966822023 cites W2109857343 @default.
• W1966822023 cites W2116151946 @default.
• W1966822023 cites W2121924211 @default.
• W1966822023 cites W2122493533 @default.
• W1966822023 cites W2125255269 @default.
• W1966822023 cites W2125863685 @default.
• W1966822023 cites W2129269993 @default.
• W1966822023 cites W2133355584 @default.
• W1966822023 cites W2139501544 @default.
• W1966822023 cites W2143000004 @default.
• W1966822023 cites W2148861929 @default.
• W1966822023 cites W2161994839 @default.
• W1966822023 cites W2165961690 @default.
• W1966822023 cites W2168158974 @default.
• W1966822023 cites W2168591865 @default.
• W1966822023 cites W2230065129 @default.
• W1966822023 doi "https://doi.org/10.1016/j.micinf.2013.08.005" @default.
• W1966822023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3842390" @default.
• W1966822023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23999313" @default.
• W1966822023 hasPublicationYear "2013" @default.
• W1966822023 type Work @default.
• W1966822023 sameAs 1966822023 @default.
• W1966822023 citedByCount "5" @default.
• W1966822023 countsByYear W19668220232014 @default.
• W1966822023 countsByYear W19668220232015 @default.
• W1966822023 countsByYear W19668220232017 @default.
• W1966822023 countsByYear W19668220232018 @default.
• W1966822023 crossrefType "journal-article" @default.
• W1966822023 hasAuthorship W1966822023A5020480735 @default.
• W1966822023 hasAuthorship W1966822023A5030088742 @default.
• W1966822023 hasAuthorship W1966822023A5035568455 @default.
• W1966822023 hasAuthorship W1966822023A5075449858 @default.
• W1966822023 hasAuthorship W1966822023A5079409467 @default.
• W1966822023 hasBestOaLocation W19668220232 @default.
• W1966822023 hasConcept C104317684 @default.
• W1966822023 hasConcept C146587185 @default.
• W1966822023 hasConcept C147483822 @default.
• W1966822023 hasConcept C159047783 @default.
• W1966822023 hasConcept C159654299 @default.
• W1966822023 hasConcept C189976730 @default.
• W1966822023 hasConcept C203014093 @default.
• W1966822023 hasConcept C22070199 @default.
• W1966822023 hasConcept C2776946954 @default.
• W1966822023 hasConcept C2780122209 @default.
• W1966822023 hasConcept C547475151 @default.
• W1966822023 hasConcept C55493867 @default.
• W1966822023 hasConcept C86803240 @default.
• W1966822023 hasConcept C8891405 @default.
• W1966822023 hasConcept C89423630 @default.
• W1966822023 hasConceptScore W1966822023C104317684 @default.
• W1966822023 hasConceptScore W1966822023C146587185 @default.
• W1966822023 hasConceptScore W1966822023C147483822 @default.
• W1966822023 hasConceptScore W1966822023C159047783 @default.
• W1966822023 hasConceptScore W1966822023C159654299 @default.
• W1966822023 hasConceptScore W1966822023C189976730 @default.
• W1966822023 hasConceptScore W1966822023C203014093 @default.
• W1966822023 hasConceptScore W1966822023C22070199 @default.
• W1966822023 hasConceptScore W1966822023C2776946954 @default.
• W1966822023 hasConceptScore W1966822023C2780122209 @default.
• W1966822023 hasConceptScore W1966822023C547475151 @default.
• W1966822023 hasConceptScore W1966822023C55493867 @default.
• W1966822023 hasConceptScore W1966822023C86803240 @default.
• W1966822023 hasConceptScore W1966822023C8891405 @default.
• W1966822023 hasConceptScore W1966822023C89423630 @default.

• next