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• W1966829421 abstract "We have identified and synthesized a brain penetrant propanoic acid as an allosteric potentiator of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency, level of potentiation and brain penetration led to the discovery of 8 (EC50=1200 nM, 77% potentiation, 119% brain/plasma in rat, 20 mpk i.p., brain level of 5700 nM)." @default.
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• W1966829421 date "2005-05-01" @default.
• W1966829421 modified "2023-10-16" @default.
• W1966829421 title "3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2)" @default.
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• W1966829421 doi "https://doi.org/10.1016/j.bmcl.2005.02.078" @default.
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