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- W1966831554 abstract "Abstract Recent studies suggested that myocardial tension during systole was an important determinant of cardiac oxygen consumption. According to the law of Laplace, a large or dilated ventricle must develop more tension in its walls than a smaller one in order to generate a given luminal pressure and is, therefore, expected to have a greater oxygen uptake. The effect of the anatomic size of the heart on the oxygen uptake per unit weight of myocardium was investigated. Experiments on the heart-lung preparation of the dog showed that the oxygen uptake in anatomically large and small hearts was the same per unit weight of tissue when aortic pressure, cardiac output, heart rate, and myocardial temperature were constant. The conclusion was that the larger heart developed more tension in its walls and used more oxygen in direct proportion to its greater number of contractile units or weight. The application of the Laplace formula to the heart must take into account the thickness and circumference of the ventricles." @default.
- W1966831554 created "2016-06-24" @default.
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- W1966831554 date "1960-12-01" @default.
- W1966831554 modified "2023-09-26" @default.
- W1966831554 title "Effect of heart size on the oxygen uptake of the myocardium" @default.
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- W1966831554 doi "https://doi.org/10.1016/0002-8703(60)90126-5" @default.
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