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• W1966831963 abstract "A total of 45 experiments were carried out to evaluate the robustness of two similar tablet formulations—a product of two strengths—with respect to normal batch-to-batch variation of the excipients and the active pharmaceutical ingredient. The formulations consist of 10 ingredients. Because of the differing amounts of active pharmaceutical ingredients, the two formulations also differ in the amounts of two of the diluents and one of the binders. The excipients and active pharmaceutical ingredient were characterized in terms of multiple variables, and principal properties were calculated with principal component analysis. A Plackett and Burman design was applied to the principal properties. The relationships between the design factors and two responses, mean disintegration time and mean crushing strength, were evaluated by using regression methods. Both formulations were found to be robust under controlled conditions." @default.
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• W1966831963 date "2006-01-01" @default.
• W1966831963 modified "2023-09-24" @default.
• W1966831963 title "Robustness Testing of a Tablet Formulation Using Multivariate Design" @default.
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• W1966831963 doi "https://doi.org/10.1080/03639040500518823" @default.
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