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- W1966836475 abstract "Tungstate treatment ameliorates experimental diabetes by increasing liver glycogen deposition through an as yet unidentified mechanism. The signalling mechanism of tungstate was studied in CHOIR cells and primary cultured hepatocytes. This compound exerted its pro-glycogenic effects through a new G-protein-dependent and Tyr-Kinase Receptor-independent mechanism. Chemical or genetic disruption of G-protein signalling prevented the activation of the Ras/ERK cascade and the downstream induction of glycogen synthesis caused by tungstate. Thus, these findings unveil a novel non-canonical signalling pathway that leads to the activation of glycogen synthesis and that could be exploited as an approach to treat diabetes." @default.
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- W1966836475 date "2012-12-19" @default.
- W1966836475 modified "2023-10-09" @default.
- W1966836475 title "Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins" @default.
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- W1966836475 doi "https://doi.org/10.1016/j.febslet.2012.11.034" @default.
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