Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966845383> ?p ?o ?g. }
- W1966845383 endingPage "348" @default.
- W1966845383 startingPage "339" @default.
- W1966845383 abstract "Exposure of mice to single-walled carbon nanotubes (SWCNTs) induces an unusually robust pulmonary inflammatory response with an early onset of fibrosis, which is accompanied by oxidative stress and antioxidant depletion. The role of specific components of the antioxidant protective system, specifically vitamin E, the major lipid-soluble antioxidant, in the SWCNT-induced reactions has not been characterized. We used C57BL/6 mice, maintained on vitamin E-sufficient or vitamin E-deficient diets, to explore and compare the pulmonary inflammatory reactions to aspired SWCNTs. The vitamin E-deficient diet caused a 90-fold depletion of alpha-tocopherol in the lung tissue and resulted in a significant decline of other antioxidants (GSH, ascorbate) as well as accumulation of lipid peroxidation products. A greater decrease of pulmonary antioxidants was detected in SWCNT-treated vitamin E-deficient mice as compared to controls. Lowered levels of antioxidants in vitamin E-deficient mice were associated with a higher sensitivity to SWCNT-induced acute inflammation (total number of inflammatory cells, number of polymorphonuclear leukocytes, released LDH, total protein content and levels of pro-inflammatory cytokines, TNF-alpha and IL-6) and enhanced profibrotic responses (elevation of TGF-beta and collagen deposition). Exposure to SWCNTs markedly shifted the ratio of cleaved to full-length extracellular superoxide dismutase (EC-SOD). Given that pulmonary levels of vitamin E can be manipulated through diet, its effects on SWCNT-induced inflammation may be of practical importance in optimizing protective strategies." @default.
- W1966845383 created "2016-06-24" @default.
- W1966845383 creator A5006031913 @default.
- W1966845383 creator A5025786667 @default.
- W1966845383 creator A5038216324 @default.
- W1966845383 creator A5053431410 @default.
- W1966845383 creator A5055133721 @default.
- W1966845383 creator A5061910944 @default.
- W1966845383 creator A5069406228 @default.
- W1966845383 creator A5069696054 @default.
- W1966845383 creator A5070620169 @default.
- W1966845383 creator A5071955516 @default.
- W1966845383 creator A5075043640 @default.
- W1966845383 date "2007-06-01" @default.
- W1966845383 modified "2023-10-12" @default.
- W1966845383 title "Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice" @default.
- W1966845383 cites W1583483795 @default.
- W1966845383 cites W1592011805 @default.
- W1966845383 cites W1954351375 @default.
- W1966845383 cites W1967678385 @default.
- W1966845383 cites W1968013150 @default.
- W1966845383 cites W1972544567 @default.
- W1966845383 cites W1973537311 @default.
- W1966845383 cites W1975059364 @default.
- W1966845383 cites W1976654942 @default.
- W1966845383 cites W1977665746 @default.
- W1966845383 cites W1983754228 @default.
- W1966845383 cites W1989291137 @default.
- W1966845383 cites W1999299952 @default.
- W1966845383 cites W2006196877 @default.
- W1966845383 cites W2008686569 @default.
- W1966845383 cites W2011058948 @default.
- W1966845383 cites W2013866322 @default.
- W1966845383 cites W2016255105 @default.
- W1966845383 cites W2017715499 @default.
- W1966845383 cites W2023785357 @default.
- W1966845383 cites W2026304182 @default.
- W1966845383 cites W2033211727 @default.
- W1966845383 cites W2036010329 @default.
- W1966845383 cites W2041701381 @default.
- W1966845383 cites W2042216921 @default.
- W1966845383 cites W2042740706 @default.
- W1966845383 cites W2055502077 @default.
- W1966845383 cites W2071583157 @default.
- W1966845383 cites W2072854658 @default.
- W1966845383 cites W2083600400 @default.
- W1966845383 cites W2088190138 @default.
- W1966845383 cites W2090042487 @default.
- W1966845383 cites W2093538276 @default.
- W1966845383 cites W2096582534 @default.
- W1966845383 cites W2097752694 @default.
- W1966845383 cites W2101343045 @default.
- W1966845383 cites W2103900156 @default.
- W1966845383 cites W2110020312 @default.
- W1966845383 cites W2115861175 @default.
- W1966845383 cites W2122594892 @default.
- W1966845383 cites W2130406156 @default.
- W1966845383 cites W2132268950 @default.
- W1966845383 cites W2154901169 @default.
- W1966845383 cites W2164781539 @default.
- W1966845383 cites W2165652357 @default.
- W1966845383 cites W2324876756 @default.
- W1966845383 cites W905836575 @default.
- W1966845383 doi "https://doi.org/10.1016/j.taap.2007.03.018" @default.
- W1966845383 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2266092" @default.
- W1966845383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17482224" @default.
- W1966845383 hasPublicationYear "2007" @default.
- W1966845383 type Work @default.
- W1966845383 sameAs 1966845383 @default.
- W1966845383 citedByCount "149" @default.
- W1966845383 countsByYear W19668453832012 @default.
- W1966845383 countsByYear W19668453832013 @default.
- W1966845383 countsByYear W19668453832014 @default.
- W1966845383 countsByYear W19668453832015 @default.
- W1966845383 countsByYear W19668453832016 @default.
- W1966845383 countsByYear W19668453832017 @default.
- W1966845383 countsByYear W19668453832018 @default.
- W1966845383 countsByYear W19668453832019 @default.
- W1966845383 countsByYear W19668453832021 @default.
- W1966845383 countsByYear W19668453832022 @default.
- W1966845383 countsByYear W19668453832023 @default.
- W1966845383 crossrefType "journal-article" @default.
- W1966845383 hasAuthorship W1966845383A5006031913 @default.
- W1966845383 hasAuthorship W1966845383A5025786667 @default.
- W1966845383 hasAuthorship W1966845383A5038216324 @default.
- W1966845383 hasAuthorship W1966845383A5053431410 @default.
- W1966845383 hasAuthorship W1966845383A5055133721 @default.
- W1966845383 hasAuthorship W1966845383A5061910944 @default.
- W1966845383 hasAuthorship W1966845383A5069406228 @default.
- W1966845383 hasAuthorship W1966845383A5069696054 @default.
- W1966845383 hasAuthorship W1966845383A5070620169 @default.
- W1966845383 hasAuthorship W1966845383A5071955516 @default.
- W1966845383 hasAuthorship W1966845383A5075043640 @default.
- W1966845383 hasBestOaLocation W19668453832 @default.
- W1966845383 hasConcept C126322002 @default.
- W1966845383 hasConcept C134018914 @default.
- W1966845383 hasConcept C181199279 @default.
- W1966845383 hasConcept C185592680 @default.