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- W1966845758 abstract "Objectives: We aimed to evaluate codon 12/13 KRAS (mKRAS) and BRAF (mBRAF) as prognostic factors in lung metastasectomy of colorectal cancer (CRC). Methods: Between January 1998 and December 2011, data from 185 patients who underwent a lung metastasectomy for CRC at the thoracic surgery department of Strasbourg University Hospital, for whom mutational status was known, were reviewed. Primary end point was overall survival (OS). Results: Mean age at time of thoracic metastasectomy was 63.35 years (±9.66). Median follow-up time was 42 months (2-122). Molecular analysis revealed mKRAS in 93 patients (51.7%) and mBRAF in 19 patients (10.6%). In univariate analysis, OS was significantly influenced by thoracic nodal status (median OS: 98 months (95% CI 83.33-112.66) for pN- patients, 27 months (95% CI 15.32-38.68) for pN + , P < 0.0001), multiple thoracic metastases (75 months vs 101 months, P = 0.008) or a history of liver metastase (94 months vs 101 months, P = 0.04). mBRAF patients had a significantly worse OS than mKRAS and WT patients (P < 0.0001). The 5-year OS was 0%, 44% and 100%, with corresponding median OS of 15 months, 55 months and 98 months respectively (P < 0.0001). In the multivariate analysis, absence of nodal involvement (HR: 0.44 (95% CI 0.27-0.73), P = 0.001), wild type BRAF (HR: 0.2 (95% CI 0.08-0.45), P < 0.0001) and wild type KRAS (HR: 0.14 (95% CI 0.05-0.39), P < 0.0001) had a significant impact on OS. Conclusions: Both mKRAS and mBRAF seem to be prognostic factors in lung metastasectomy of CRC. Further studies are necessary to validate these results. Disclosure: No significant relationships." @default.
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- W1966845758 date "2014-06-01" @default.
- W1966845758 modified "2023-09-26" @default.
- W1966845758 title "F-077 * KRAS AND BRAF MUTATIONS ARE PROGNOSTIC BIOMARKERS IN PATIENTS UNDERGOING LUNG METASTASECTOMY OF COLORECTAL CANCER" @default.
- W1966845758 doi "https://doi.org/10.1093/icvts/ivu167.77" @default.
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