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- W1966853588 abstract "With great interest we read the paper by Sauver et al. on participation i.e. (self) selection bias in their study on the association between human leukocyte antigen (HLA) gene variants and measles-mumps-rubella (MMR) vaccination-induced immunity. Participation bias is an important subject as it affects almost all studies involving human subjects. Nevertheless in most studies little or no information is collected on non-responders. The authors therefore have to be commended for exploring this issue in great detail by obtaining access to data collected in a larger study from which the present study population (children and adolescents aged 12-18) was randomly sampled. They identified several factors associated with participation such as ethnicity (Somali children were less likely to participate) and use of health care (children using more health care maybe unhealthier children were more likely to participate). The authors conclude that this selection may have biased their results. However we are not sure. In any case their argument that a selection on the basis of subtly poorer health and therefore more children with HLA alleles associated with low immunity to the MMR vaccine antigens fails to convince. (excerpt)" @default.
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- W1966853588 date "2007-11-01" @default.
- W1966853588 modified "2023-10-14" @default.
- W1966853588 title "Assessing participation bias in a population-based study of measles-mumps-rubella vaccine immunity in children and adolescents aged 12–18" @default.
- W1966853588 cites W2162486971 @default.
- W1966853588 doi "https://doi.org/10.1111/j.1365-3016.2007.00886.x" @default.
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