Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966853872> ?p ?o ?g. }
- W1966853872 endingPage "428" @default.
- W1966853872 startingPage "413" @default.
- W1966853872 abstract "Effect of agmatine (10–400 mg/kg) on neuropathic pain in a rat model produced by loose ligatures around the common sciatic nerve was studied. The involvement of possible alterations in nitric oxide (NO) levels [measured as its stable metabolites nitrate + nitrite] and in noradrenergic activity [measured as norepinephrine and 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) levels] in this effect was also investigated biochemically in the brainstem and cerebellum. Agmatine increased the neuropathic pain threshold at 300 and 400 mg/kg. There was almost a twofold increase in nitrate + nitrite levels in the brainstem and cerebellum of the rats with neuropathic pain and agmatine decreased the high nitrate + nitrite levels only in the brainstem at 300 mg/kg and both in the brainstem and cerebellum at 400 mg/kg. Ligation of sciatic nerve resulted in almost twofold increase in norepinephrine and MHPG levels only in the brainstem of the rats. Agmatine decreased MHPG levels at 300 and 400 mg/kg, however it decreased norepinephrine levels only at the higher dose. These findings indicate that agmatine decreases neuropathic pain, an effect which may involve the reduction of NO levels and noradrenergic activity in the brain." @default.
- W1966853872 created "2016-06-24" @default.
- W1966853872 creator A5000841758 @default.
- W1966853872 creator A5003814995 @default.
- W1966853872 creator A5032289474 @default.
- W1966853872 creator A5041703014 @default.
- W1966853872 date "2003-06-01" @default.
- W1966853872 modified "2023-10-11" @default.
- W1966853872 title "Agmatine attenuates neuropathic pain in rats: Possible mediation of nitric oxide and noradrenergic activity in the brainstem and cerebellum" @default.
- W1966853872 cites W1965296964 @default.
- W1966853872 cites W1965948569 @default.
- W1966853872 cites W1966322594 @default.
- W1966853872 cites W1969389571 @default.
- W1966853872 cites W1969784828 @default.
- W1966853872 cites W1970106628 @default.
- W1966853872 cites W1979537470 @default.
- W1966853872 cites W1981999620 @default.
- W1966853872 cites W1987139868 @default.
- W1966853872 cites W1988146090 @default.
- W1966853872 cites W1988980312 @default.
- W1966853872 cites W1989804049 @default.
- W1966853872 cites W1992166409 @default.
- W1966853872 cites W1996948567 @default.
- W1966853872 cites W1998126770 @default.
- W1966853872 cites W2004087403 @default.
- W1966853872 cites W2005022730 @default.
- W1966853872 cites W2006983639 @default.
- W1966853872 cites W2007415551 @default.
- W1966853872 cites W2007974062 @default.
- W1966853872 cites W2012682261 @default.
- W1966853872 cites W2013040468 @default.
- W1966853872 cites W2014570809 @default.
- W1966853872 cites W2015630446 @default.
- W1966853872 cites W2022476275 @default.
- W1966853872 cites W2024862570 @default.
- W1966853872 cites W2030643293 @default.
- W1966853872 cites W2031791494 @default.
- W1966853872 cites W2033001509 @default.
- W1966853872 cites W2035043853 @default.
- W1966853872 cites W2035960661 @default.
- W1966853872 cites W2036776086 @default.
- W1966853872 cites W2037557735 @default.
- W1966853872 cites W2039156019 @default.
- W1966853872 cites W2039311197 @default.
- W1966853872 cites W2040010122 @default.
- W1966853872 cites W2041476994 @default.
- W1966853872 cites W2045798386 @default.
- W1966853872 cites W2048853229 @default.
- W1966853872 cites W2049005778 @default.
- W1966853872 cites W2052716657 @default.
- W1966853872 cites W2058020736 @default.
- W1966853872 cites W2059588207 @default.
- W1966853872 cites W2059847469 @default.
- W1966853872 cites W2060865110 @default.
- W1966853872 cites W2065754131 @default.
- W1966853872 cites W2067112170 @default.
- W1966853872 cites W2072686777 @default.
- W1966853872 cites W2074547495 @default.
- W1966853872 cites W2082897509 @default.
- W1966853872 cites W2086524100 @default.
- W1966853872 cites W2118295691 @default.
- W1966853872 cites W2123269821 @default.
- W1966853872 cites W2138637179 @default.
- W1966853872 cites W2151866626 @default.
- W1966853872 cites W2164595237 @default.
- W1966853872 cites W2223031716 @default.
- W1966853872 cites W2313326603 @default.
- W1966853872 cites W2410941556 @default.
- W1966853872 cites W2883536523 @default.
- W1966853872 cites W4230329824 @default.
- W1966853872 doi "https://doi.org/10.1016/s0024-3205(03)00297-2" @default.
- W1966853872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12759136" @default.
- W1966853872 hasPublicationYear "2003" @default.
- W1966853872 type Work @default.
- W1966853872 sameAs 1966853872 @default.
- W1966853872 citedByCount "63" @default.
- W1966853872 countsByYear W19668538722012 @default.
- W1966853872 countsByYear W19668538722013 @default.
- W1966853872 countsByYear W19668538722014 @default.
- W1966853872 countsByYear W19668538722015 @default.
- W1966853872 countsByYear W19668538722016 @default.
- W1966853872 countsByYear W19668538722017 @default.
- W1966853872 countsByYear W19668538722018 @default.
- W1966853872 countsByYear W19668538722019 @default.
- W1966853872 countsByYear W19668538722020 @default.
- W1966853872 countsByYear W19668538722021 @default.
- W1966853872 countsByYear W19668538722022 @default.
- W1966853872 countsByYear W19668538722023 @default.
- W1966853872 crossrefType "journal-article" @default.
- W1966853872 hasAuthorship W1966853872A5000841758 @default.
- W1966853872 hasAuthorship W1966853872A5003814995 @default.
- W1966853872 hasAuthorship W1966853872A5032289474 @default.
- W1966853872 hasAuthorship W1966853872A5041703014 @default.
- W1966853872 hasConcept C126322002 @default.
- W1966853872 hasConcept C134018914 @default.
- W1966853872 hasConcept C185592680 @default.
- W1966853872 hasConcept C2777107010 @default.
- W1966853872 hasConcept C2777468819 @default.