Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966854313> ?p ?o ?g. }
- W1966854313 endingPage "232" @default.
- W1966854313 startingPage "228" @default.
- W1966854313 abstract "Abstract Mycobacterium tuberculosis , the causal agent of pulmonary tuberculosis (TB), remains a major health problem throughout the world causing high mortality in humans. Previous studies showed that several genes may play crucial roles in susceptibility to TB. The PTPN22 gene encodes the lymphoid tyrosine phosphatase that has an important regulatory effect on T‐ and B‐cell activation in immune response. The purpose of this study was to investigate the role of two functional missense single nucleotide polymorphisms (SNPs) of the PTPN22 gene region (R620W and R263Q) in the susceptibility to TB in the Moroccan population. A case–control association study was performed including 123 pulmonary TB patients and 155 healthy controls. All subjects were genotyped by TaqMan SNP genotyping assays. Regarding the PTPN22 R620W (C1858T) SNP, we observed a statistically significant difference in the distribution of the PTPN22 1885T allele between pulmonary TB patients and healthy controls (0.41% vs 3.2%, P = 0.01, odds ratio (OR) = 0.14, 95% confidence interval (CI) = 0.01–0.93). With respect to the PTPN22 R263Q (G788A), we observed an increase of 788A allele frequencies in TB patients compared with those in healthy controls (3.65% vs 0.65%, P = 0.01, OR = 5.85, 95% CI = 1.17–39.55). These results suggest that PTPN22 gene variants may affect susceptibility to TB in the Moroccan population." @default.
- W1966854313 created "2016-06-24" @default.
- W1966854313 creator A5003229159 @default.
- W1966854313 creator A5003364619 @default.
- W1966854313 creator A5011384964 @default.
- W1966854313 creator A5017695560 @default.
- W1966854313 creator A5026853575 @default.
- W1966854313 creator A5039280657 @default.
- W1966854313 creator A5064296895 @default.
- W1966854313 date "2009-08-05" @default.
- W1966854313 modified "2023-10-12" @default.
- W1966854313 title "Association of<i>PTPN22</i>gene functional variants with development of pulmonary tuberculosis in Moroccan population" @default.
- W1966854313 cites W1554963629 @default.
- W1966854313 cites W163644054 @default.
- W1966854313 cites W1987677365 @default.
- W1966854313 cites W1990845353 @default.
- W1966854313 cites W1992680340 @default.
- W1966854313 cites W1994402720 @default.
- W1966854313 cites W2002599058 @default.
- W1966854313 cites W2003947050 @default.
- W1966854313 cites W202009046 @default.
- W1966854313 cites W2020988840 @default.
- W1966854313 cites W2026992690 @default.
- W1966854313 cites W2037912735 @default.
- W1966854313 cites W2046225888 @default.
- W1966854313 cites W2046383867 @default.
- W1966854313 cites W2073204194 @default.
- W1966854313 cites W2079722764 @default.
- W1966854313 cites W2082305090 @default.
- W1966854313 cites W2087265576 @default.
- W1966854313 cites W2092034926 @default.
- W1966854313 cites W2098791282 @default.
- W1966854313 cites W2101316867 @default.
- W1966854313 cites W2104941073 @default.
- W1966854313 cites W2106959446 @default.
- W1966854313 cites W2109642702 @default.
- W1966854313 cites W2113491191 @default.
- W1966854313 cites W2121647674 @default.
- W1966854313 cites W2123584222 @default.
- W1966854313 cites W2127377326 @default.
- W1966854313 cites W2138590566 @default.
- W1966854313 cites W2142628971 @default.
- W1966854313 cites W2142882662 @default.
- W1966854313 cites W2147026827 @default.
- W1966854313 cites W2155102587 @default.
- W1966854313 cites W2163735374 @default.
- W1966854313 cites W4210749876 @default.
- W1966854313 cites W4243772775 @default.
- W1966854313 cites W4246916591 @default.
- W1966854313 doi "https://doi.org/10.1111/j.1399-0039.2009.01304.x" @default.
- W1966854313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19563523" @default.
- W1966854313 hasPublicationYear "2009" @default.
- W1966854313 type Work @default.
- W1966854313 sameAs 1966854313 @default.
- W1966854313 citedByCount "45" @default.
- W1966854313 countsByYear W19668543132012 @default.
- W1966854313 countsByYear W19668543132013 @default.
- W1966854313 countsByYear W19668543132014 @default.
- W1966854313 countsByYear W19668543132015 @default.
- W1966854313 countsByYear W19668543132016 @default.
- W1966854313 countsByYear W19668543132017 @default.
- W1966854313 countsByYear W19668543132018 @default.
- W1966854313 countsByYear W19668543132019 @default.
- W1966854313 countsByYear W19668543132020 @default.
- W1966854313 countsByYear W19668543132021 @default.
- W1966854313 countsByYear W19668543132022 @default.
- W1966854313 crossrefType "journal-article" @default.
- W1966854313 hasAuthorship W1966854313A5003229159 @default.
- W1966854313 hasAuthorship W1966854313A5003364619 @default.
- W1966854313 hasAuthorship W1966854313A5011384964 @default.
- W1966854313 hasAuthorship W1966854313A5017695560 @default.
- W1966854313 hasAuthorship W1966854313A5026853575 @default.
- W1966854313 hasAuthorship W1966854313A5039280657 @default.
- W1966854313 hasAuthorship W1966854313A5064296895 @default.
- W1966854313 hasConcept C104317684 @default.
- W1966854313 hasConcept C126322002 @default.
- W1966854313 hasConcept C135763542 @default.
- W1966854313 hasConcept C139275648 @default.
- W1966854313 hasConcept C142724271 @default.
- W1966854313 hasConcept C146304588 @default.
- W1966854313 hasConcept C153209595 @default.
- W1966854313 hasConcept C156957248 @default.
- W1966854313 hasConcept C180754005 @default.
- W1966854313 hasConcept C203014093 @default.
- W1966854313 hasConcept C2779356809 @default.
- W1966854313 hasConcept C2781069245 @default.
- W1966854313 hasConcept C2908647359 @default.
- W1966854313 hasConcept C31467283 @default.
- W1966854313 hasConcept C54355233 @default.
- W1966854313 hasConcept C71924100 @default.
- W1966854313 hasConcept C86803240 @default.
- W1966854313 hasConcept C99454951 @default.
- W1966854313 hasConceptScore W1966854313C104317684 @default.
- W1966854313 hasConceptScore W1966854313C126322002 @default.
- W1966854313 hasConceptScore W1966854313C135763542 @default.
- W1966854313 hasConceptScore W1966854313C139275648 @default.
- W1966854313 hasConceptScore W1966854313C142724271 @default.
- W1966854313 hasConceptScore W1966854313C146304588 @default.