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- W1966861727 abstract "Hyperthermia (HT) enhances cytotoxicity of cisplatin (CDDP). If this enhancement is different in untreated versus irradiated tumours is not known. Therefore this animal study investigates the efficacy of combined CDDP and HT in untreated tumours compared to tumours regrowing after irradiation. Pieces of R-1 rhabdomyosarcoma were subcutaneously implanted in the hind legs of Wag/Ry rats. After irradiation, the tumours regrew to their original volumes within 16 days. Chemo-hyperthermic treatment of untreated tumours or irradiated tumours at day 16 after irradiation consisted of CDDP (6 mg/kg ip), HT (1 h at 43°C) or CDDP + HT (45 min interval). The experimental endpoint was tumour growth delay (TGD). In untreated tumours CDDP + HT resulted in a significantly larger TGD than CDDP alone (11.6 and 7.4 days respectively, P = 0.0002), while HT alone showed a 1-day TGD. Preliminary results in irradiated tumours indicate that CDDP + HT rendered a similar TGD as in untreated tumours, although the TGD after CDDP + HT was not significantly different from CDDP alone. Our findings show that HT enhances the effectiveness of CDDP in R-1 tumours. Untreated tumours probably respond similar to CDDP + HT as compared to irradiated tumours." @default.
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- W1966861727 date "1995-11-01" @default.
- W1966861727 modified "2023-09-28" @default.
- W1966861727 title "842 Hyperthermia-enhanced effectiveness of cisplatin in untreated versus irradiated rat solid tumours" @default.
- W1966861727 doi "https://doi.org/10.1016/0959-8049(95)96091-q" @default.
- W1966861727 hasPublicationYear "1995" @default.
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