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• W1966863313 abstract "Significance Conjugate vaccines have dramatically reduced the incidence of disease in infants and young children caused by encapsulated bacterial pathogens. These vaccines, however, are difficult and expensive to manufacture, deterring their widespread use. We present an alternative technology for the production of conjugate-like vaccines whereby capsular antigens are entrapped in a cross-linked protein matrix. The versatility and ease of protein capsular matrix vaccine production compared with conjugates will likely render the manufacture of these vaccines simpler and more cost effective than conjugate vaccines. This in turn would improve the availability of such vaccines to the developing world, which has shown a limited capacity to afford the cost of conventional conjugate vaccines." @default.
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• W1966863313 date "2015-02-19" @default.
• W1966863313 modified "2023-10-11" @default.
• W1966863313 title "Conjugate-like immunogens produced as protein capsular matrix vaccines" @default.
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• W1966863313 doi "https://doi.org/10.1073/pnas.1425005112" @default.
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