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• W1966877296 abstract "The major breakthrough in the treatment of ankylosing spondylitis (AS) came in 2003 with the approval of the first two TNF inhibitors (TNFi) [1]. Since then, three additional TNFi have been approved for the treatment of AS, but biologics with different mechanisms of action (e.g., anakinra, abatacept, tocilizumab) were found to be not efficacious in these patients [2]. In 2009, the Assessment of SpondyloArthritis International Society (ASAS) redefined the spectrum of axial inflammatory diseases by developing classification criteria for axial spondyloarthritis (axSpA), an umbrella term that includes AS and non-radiographic axSpA (nr-axSpA) [3]. Only a few trials since the reclassification have included subjects from the entire spectrum of axSpA or those with nr-axSpA [4–6]. Despite these advances, pharmaceutical interventions for axSpA are quite limited compared with other chronic inflammatory diseases such as rheumatoid arthritis (RA). Some major unresolved questions and possible challenges for future studies in the treatment of axSpA are shown in Table 1." @default.
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• W1966877296 date "2014-07-13" @default.
• W1966877296 modified "2023-10-12" @default.
• W1966877296 title "Unanswered questions in the management of axial spondyloarthritis: an opinion piece" @default.
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• W1966877296 doi "https://doi.org/10.1007/s10067-014-2740-x" @default.
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