Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966877544> ?p ?o ?g. }
- W1966877544 endingPage "509" @default.
- W1966877544 startingPage "502" @default.
- W1966877544 abstract "In the current study, neuroprotective effect of the essential oil and aromatic waters of rose was investigated by in vitro and in silico methods. The samples were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Since oxidative damage is associated with neurodegeneration, antioxidant activity of the samples was determined by DPPH radical scavenging, metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. Their chemical composition was elucidated by GC–MS. Anti-cholinesterase effects of the main components (citronellol, geraniol, nerol, and phenylethyl alcohol) were also examined. The rose oil showed a noteworthy inhibition against AChE (60.86 ± 1.99%) and BChE (51.08 ± 1.70%) at 1000 μg/mL and low activity in DPPH radical scavenging and FRAP tests. Phenylethyl alcohol exerted higher cholinesterase inhibition than other components and applied further to molecular docking simulations. Docking and binding energies supporting experimental results show that the compound is more selective towards BChE than AChE." @default.
- W1966877544 created "2016-06-24" @default.
- W1966877544 creator A5004481451 @default.
- W1966877544 creator A5006401294 @default.
- W1966877544 creator A5059211339 @default.
- W1966877544 creator A5063632267 @default.
- W1966877544 creator A5077276290 @default.
- W1966877544 creator A5084633782 @default.
- W1966877544 creator A5091216509 @default.
- W1966877544 date "2013-08-01" @default.
- W1966877544 modified "2023-10-03" @default.
- W1966877544 title "A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.)" @default.
- W1966877544 cites W1867176171 @default.
- W1966877544 cites W1941429996 @default.
- W1966877544 cites W1971048984 @default.
- W1966877544 cites W1974783514 @default.
- W1966877544 cites W1977884135 @default.
- W1966877544 cites W1978268843 @default.
- W1966877544 cites W1985028250 @default.
- W1966877544 cites W1986961578 @default.
- W1966877544 cites W2017427945 @default.
- W1966877544 cites W2021995332 @default.
- W1966877544 cites W2029087609 @default.
- W1966877544 cites W2031596649 @default.
- W1966877544 cites W2034204104 @default.
- W1966877544 cites W2042327967 @default.
- W1966877544 cites W2043043846 @default.
- W1966877544 cites W2052047862 @default.
- W1966877544 cites W2057491831 @default.
- W1966877544 cites W2060962914 @default.
- W1966877544 cites W2068524720 @default.
- W1966877544 cites W2081912151 @default.
- W1966877544 cites W2085977908 @default.
- W1966877544 cites W2095469446 @default.
- W1966877544 cites W2098437204 @default.
- W1966877544 cites W2143410390 @default.
- W1966877544 cites W2144571979 @default.
- W1966877544 cites W2145474776 @default.
- W1966877544 cites W2149366413 @default.
- W1966877544 cites W2152165298 @default.
- W1966877544 cites W2166114438 @default.
- W1966877544 cites W2167292970 @default.
- W1966877544 cites W2167557753 @default.
- W1966877544 cites W2354350348 @default.
- W1966877544 cites W4367165742 @default.
- W1966877544 doi "https://doi.org/10.1016/j.foodres.2013.05.031" @default.
- W1966877544 hasPublicationYear "2013" @default.
- W1966877544 type Work @default.
- W1966877544 sameAs 1966877544 @default.
- W1966877544 citedByCount "31" @default.
- W1966877544 countsByYear W19668775442015 @default.
- W1966877544 countsByYear W19668775442016 @default.
- W1966877544 countsByYear W19668775442017 @default.
- W1966877544 countsByYear W19668775442018 @default.
- W1966877544 countsByYear W19668775442019 @default.
- W1966877544 countsByYear W19668775442020 @default.
- W1966877544 countsByYear W19668775442021 @default.
- W1966877544 countsByYear W19668775442022 @default.
- W1966877544 countsByYear W19668775442023 @default.
- W1966877544 crossrefType "journal-article" @default.
- W1966877544 hasAuthorship W1966877544A5004481451 @default.
- W1966877544 hasAuthorship W1966877544A5006401294 @default.
- W1966877544 hasAuthorship W1966877544A5059211339 @default.
- W1966877544 hasAuthorship W1966877544A5063632267 @default.
- W1966877544 hasAuthorship W1966877544A5077276290 @default.
- W1966877544 hasAuthorship W1966877544A5084633782 @default.
- W1966877544 hasAuthorship W1966877544A5091216509 @default.
- W1966877544 hasConcept C181199279 @default.
- W1966877544 hasConcept C185592680 @default.
- W1966877544 hasConcept C2775907625 @default.
- W1966877544 hasConcept C2776231299 @default.
- W1966877544 hasConcept C2777278459 @default.
- W1966877544 hasConcept C2778004101 @default.
- W1966877544 hasConcept C2778240251 @default.
- W1966877544 hasConcept C2778816929 @default.
- W1966877544 hasConcept C2779059548 @default.
- W1966877544 hasConcept C2779101902 @default.
- W1966877544 hasConcept C2779554281 @default.
- W1966877544 hasConcept C2781401929 @default.
- W1966877544 hasConcept C31896038 @default.
- W1966877544 hasConcept C31903555 @default.
- W1966877544 hasConcept C55493867 @default.
- W1966877544 hasConcept C71240020 @default.
- W1966877544 hasConcept C71924100 @default.
- W1966877544 hasConcept C98274493 @default.
- W1966877544 hasConceptScore W1966877544C181199279 @default.
- W1966877544 hasConceptScore W1966877544C185592680 @default.
- W1966877544 hasConceptScore W1966877544C2775907625 @default.
- W1966877544 hasConceptScore W1966877544C2776231299 @default.
- W1966877544 hasConceptScore W1966877544C2777278459 @default.
- W1966877544 hasConceptScore W1966877544C2778004101 @default.
- W1966877544 hasConceptScore W1966877544C2778240251 @default.
- W1966877544 hasConceptScore W1966877544C2778816929 @default.
- W1966877544 hasConceptScore W1966877544C2779059548 @default.
- W1966877544 hasConceptScore W1966877544C2779101902 @default.
- W1966877544 hasConceptScore W1966877544C2779554281 @default.
- W1966877544 hasConceptScore W1966877544C2781401929 @default.
- W1966877544 hasConceptScore W1966877544C31896038 @default.