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• W1966883507 abstract "Biotransport of nitric oxide (NO) and of oxygen (O2) in the microcirculation are inherently interdependent, since all nitric oxide synthase (NOS) isoforms (eNOS, nNOS, and iNOS) require O2 to produce NO. Furthermore, tissue O2 consumption is reversibly inhibited by NO. To investigate these complex interactions, a mathematical model was developed for coupled mass transport of NO and O2 around a cylindrical arteriole using finite element computational methods. Steady-state radial NO and O2 gradients in the bloodstream, plasma layer, endothelium, vascular wall, and surrounding tissue were simulated for different conditions. Special cases of the model were solved, including O2-dependent NO production from eNOS alone, and with additional NO production from either nNOS or iNOS at specified locations. The model predicts that (a) concentration changes in one species can have significant effects on transport of the other species with the degree of interaction dependent on spatial gradients; (b) eNOS NO production rates required to maintain the concentration of NO in the vascular wall are more dependent on NO scavenging in blood than in tissue; (c) relatively low rates of NO production in tissue from either nNOS or iNOS can elevate vascular wall NO, compensating for possible reductions in NO production from eNOS; (d) depending on their physical location, nNOS and iNOS can be very sensitive to O2; and (e) increased tissue NO can increase O2 delivery to more distal regions by inhibiting O2 consumption in other regions." @default.
• W1966883507 created "2016-06-24" @default.
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• W1966883507 date "2004-07-01" @default.
• W1966883507 modified "2023-10-15" @default.
• W1966883507 title "Interactions between NO and O2 in the microcirculation: a mathematical analysis" @default.
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• W1966883507 doi "https://doi.org/10.1016/j.mvr.2004.03.001" @default.
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