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- W1966885655 endingPage "964" @default.
- W1966885655 startingPage "949" @default.
- W1966885655 abstract "Insulin signalling is uniquely required for storing energy as fat in humans. While de novo synthesis of fatty acids and triacylglycerol occurs mostly in liver, adipose tissue is the primary site for triacylglycerol storage. Insulin signalling mechanisms in adipose tissue that stimulate hydrolysis of circulating triacylglycerol, uptake of the released fatty acids and their conversion to triacylglycerol are poorly understood. New findings include (1) activation of DNA-dependent protein kinase to stimulate upstream stimulatory factor (USF)1/USF2 heterodimers, enhancing the lipogenic transcription factor sterol regulatory element binding protein 1c (SREBP1c); (2) stimulation of fatty acid synthase through AMP kinase modulation; (3) mobilisation of lipid droplet proteins to promote retention of triacylglycerol; and (4) upregulation of a novel carbohydrate response element binding protein β isoform that potently stimulates transcription of lipogenic enzymes. Additionally, insulin signalling through mammalian target of rapamycin to activate transcription and processing of SREBP1c described in liver may apply to adipose tissue. Paradoxically, insulin resistance in obesity and type 2 diabetes is associated with increased triacylglycerol synthesis in liver, while it is decreased in adipose tissue. This and other mysteries about insulin signalling and insulin resistance in adipose tissue make this topic especially fertile for future research." @default.
- W1966885655 created "2016-06-24" @default.
- W1966885655 creator A5019117620 @default.
- W1966885655 creator A5027528311 @default.
- W1966885655 creator A5085687728 @default.
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- W1966885655 date "2013-02-27" @default.
- W1966885655 modified "2023-10-11" @default.
- W1966885655 title "Insulin signalling mechanisms for triacylglycerol storage" @default.
- W1966885655 cites W1504753880 @default.
- W1966885655 cites W1534360145 @default.
- W1966885655 cites W1537149240 @default.
- W1966885655 cites W1547990180 @default.
- W1966885655 cites W1561220511 @default.
- W1966885655 cites W1582691127 @default.
- W1966885655 cites W1595083713 @default.
- W1966885655 cites W1748636648 @default.
- W1966885655 cites W1764140709 @default.
- W1966885655 cites W1827488762 @default.
- W1966885655 cites W1938589063 @default.
- W1966885655 cites W1964662291 @default.
- W1966885655 cites W1966217610 @default.
- W1966885655 cites W1966336914 @default.
- W1966885655 cites W1966723744 @default.
- W1966885655 cites W1967724716 @default.
- W1966885655 cites W1969032539 @default.
- W1966885655 cites W1969411755 @default.
- W1966885655 cites W1970306975 @default.
- W1966885655 cites W1970382695 @default.
- W1966885655 cites W1971776904 @default.
- W1966885655 cites W1972681777 @default.
- W1966885655 cites W1974134896 @default.
- W1966885655 cites W1978476677 @default.
- W1966885655 cites W1978881179 @default.
- W1966885655 cites W1980663997 @default.
- W1966885655 cites W1981043027 @default.
- W1966885655 cites W1982281255 @default.
- W1966885655 cites W1982659014 @default.
- W1966885655 cites W1983411407 @default.
- W1966885655 cites W1985123547 @default.
- W1966885655 cites W1985806842 @default.
- W1966885655 cites W1986938616 @default.
- W1966885655 cites W1988870963 @default.
- W1966885655 cites W1989521310 @default.
- W1966885655 cites W1989829058 @default.
- W1966885655 cites W1991079474 @default.
- W1966885655 cites W19928905 @default.
- W1966885655 cites W1995687483 @default.
- W1966885655 cites W1995939711 @default.
- W1966885655 cites W1997459346 @default.
- W1966885655 cites W1998265194 @default.
- W1966885655 cites W1998493448 @default.
- W1966885655 cites W2000558897 @default.
- W1966885655 cites W2000815833 @default.
- W1966885655 cites W2001736800 @default.
- W1966885655 cites W2003260371 @default.
- W1966885655 cites W2003755391 @default.
- W1966885655 cites W2006895230 @default.
- W1966885655 cites W2008381613 @default.
- W1966885655 cites W2009172922 @default.
- W1966885655 cites W2009365923 @default.
- W1966885655 cites W2009624930 @default.
- W1966885655 cites W2009781469 @default.
- W1966885655 cites W2010734699 @default.
- W1966885655 cites W2010957046 @default.
- W1966885655 cites W2011437165 @default.
- W1966885655 cites W2012794496 @default.
- W1966885655 cites W2013829707 @default.
- W1966885655 cites W2015384831 @default.
- W1966885655 cites W2018192258 @default.
- W1966885655 cites W2019066384 @default.
- W1966885655 cites W2020960565 @default.
- W1966885655 cites W2021025717 @default.
- W1966885655 cites W2021632088 @default.
- W1966885655 cites W2021710604 @default.
- W1966885655 cites W2022316151 @default.
- W1966885655 cites W2022986290 @default.
- W1966885655 cites W2023430066 @default.
- W1966885655 cites W2024661492 @default.
- W1966885655 cites W2025578932 @default.
- W1966885655 cites W2026444406 @default.
- W1966885655 cites W2027273404 @default.
- W1966885655 cites W2028782957 @default.
- W1966885655 cites W2029383686 @default.
- W1966885655 cites W2031874852 @default.
- W1966885655 cites W2033531132 @default.
- W1966885655 cites W2033946555 @default.
- W1966885655 cites W2034541077 @default.
- W1966885655 cites W2035617239 @default.
- W1966885655 cites W2036344921 @default.
- W1966885655 cites W2038558726 @default.
- W1966885655 cites W2038904723 @default.
- W1966885655 cites W2039928578 @default.
- W1966885655 cites W2044013713 @default.
- W1966885655 cites W2046395262 @default.
- W1966885655 cites W2047641209 @default.
- W1966885655 cites W2048721122 @default.
- W1966885655 cites W2049078566 @default.