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- W1966888912 abstract "The interactions of DNA with oxaliplatin (Pt(R,R-DACH)) or its enantiomer (Pt(S,S-DACH)) were investigated using magnetic tweezers and atomic force microscope. In the process of DNA condensation induced by Pt-DACH, only diadducts and micro-loops are formed at low Pt-DACH concentrations, while at high Pt-DACH concentrations, besides the diadducts and micro-loops, long-range cross-links are also formed. The diadduct formation rate of Pt(R,R-DACH) is higher than that of Pt(S,S-DACH). However, the proportions of micro-loops and long-range cross-links for Pt(S,S-DACH) are higher than those for Pt(R,R-DACH). We propose a model to explain these differences between the effect of Pt(R,R-DACH) and that of Pt(S,S-DACH) on DNA condensation. The study has strong implications for the understanding of the effect of chirality on the interaction between Pt-DACH and DNA and the kinetics of DNA condensation induced by platinum complexes." @default.
- W1966888912 created "2016-06-24" @default.
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- W1966888912 date "2013-08-12" @default.
- W1966888912 modified "2023-10-16" @default.
- W1966888912 title "Oxaliplatin and Its Enantiomer Induce Different Condensation Dynamics of Single DNA Molecules" @default.
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- W1966888912 doi "https://doi.org/10.1371/journal.pone.0071556" @default.
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